Description

(2R,3S)-2-Amino-3-Methyl-Pentanoic Acid Methyl Ester Hydrochloride is a high-purity chiral building block and protected amino acid derivative essential for advanced organic synthesis. Its defined stereochemistry makes it a critical intermediate for constructing complex molecules with precise three-dimensional architecture. This compound is primarily utilized by research institutions and pharmaceutical companies in the development of novel active pharmaceutical ingredients (APIs), peptides, and other fine chemicals where stereochemical integrity is paramount.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the research and production of enantiomerically pure drugs and bioactive compounds.
• Peptide Synthesis: Serves as a protected amino acid ester in solid-phase and solution-phase peptide chemistry.
• Asymmetric Synthesis: Used as a starting material or auxiliary in catalytic asymmetric reactions to introduce stereogenic centers.
• Chemical Research: Valuable reference standard and building block in medicinal chemistry and process development laboratories.
• Agrochemical Development: Intermediate in the synthesis of chiral pesticides and herbicides with specific biological activity.

Basic Information

Product Name	(2R,3S)-2-Amino-3-Methyl-Pentanoic Acid Methyl Ester Hydrochloride
CAS No.	60667-85-8
Molecular Formula	C7H16ClNO2
Molecular Weight	181.66 g/mol
Synonyms	L-Isoleucine methyl ester hydrochloride; (2R,3S)-2-Amino-3-methylpentanoic acid methyl ester hydrochloride; Methyl L-isoleucinate hydrochloride; (2R,3S)-Isoleucine methyl ester HCl; (2R,3S)-2-Amino-3-methylvaleric acid methyl ester hydrochloride; L-Ile-OMe·HCl; Methyl (2R,3S)-2-amino-3-methylpentanoate hydrochloride
EINECS	Contact for details

Quality Control

Our (2R,3S)-2-Amino-3-Methyl-Pentanoic Acid Methyl Ester Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research and development. A Certificate of Analysis (COA) detailing identity, purity, and specific rotation is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Specific Rotation	Contact for details
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.