Description

(4R)-4-Fluoro-L-Proline Hcl is a fluorinated derivative of the amino acid proline, specifically engineered to introduce conformational rigidity and metabolic stability into peptide and protein structures. This compound is a critical chiral building block in modern pharmaceutical research and development, enabling the fine-tuning of biological activity and pharmacokinetic properties. It is primarily sought after by researchers and manufacturers in the pharmaceutical, biotechnology, and agrochemical sectors for applications in drug discovery, peptide synthesis, and the development of novel bioactive molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel drug candidates, particularly protease inhibitors and other enzyme-targeted therapeutics.
• Peptide Engineering: Used to incorporate fluoroproline residues into peptides to enhance their stability against enzymatic degradation and influence secondary structure (e.g., collagen mimetics).
• Bioconjugation & Probe Development: Serves as a building block for creating fluorescent or affinity-labeled peptides for biochemical and diagnostic assays.
• Agrochemical Research: Employed in the development of novel peptides with pesticidal or plant growth-regulating activity.
• Academic & Contract Research: Essential for fundamental research in medicinal chemistry, structural biology, and peptide science.

Basic Information

Item	Detail
Product Name	(4R)-4-Fluoro-L-Proline Hydrochloride
CAS No.	60604-36-6
Molecular Formula	C5H9FNO2 • HCl
Molecular Weight	169.59 (Free base) / 206.05 (HCl salt)
Synonyms	(4R)-4-Fluoro-L-proline hydrochloride; (R)-4-Fluoroproline hydrochloride; L-4-Fluoroproline HCl; 4(R)-Fluoroproline hydrochloride; trans-4-Fluoro-L-proline hydrochloride; 4-Fluoro-L-proline HCl; (2S,4R)-4-Fluoropyrrolidine-2-carboxylic acid hydrochloride; FPro-OH•HCl
EINECS	Contact for details

Quality Control

Our (4R)-4-Fluoro-L-Proline Hcl is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and development applications. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.