Description

H-D-Allo-Thr-Ome Hcl is a protected derivative of the non-proteinogenic amino acid allo-threonine, specifically the H-D-Allo-Thr-OMe hydrochloride salt. This compound is a crucial chiral building block and intermediate in advanced organic synthesis, particularly for the development of pharmaceuticals and bioactive peptides. It is primarily utilized by research institutions and chemical manufacturers engaged in the production of novel therapeutic agents, peptide mimetics, and complex organic molecules where stereochemical control is paramount.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the synthesis of active pharmaceutical ingredients (APIs) and investigational new drugs.
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis to incorporate the allo-threonine residue with a protected carboxylic acid (methyl ester) and a free amine, enabling specific chain elongation.
• Protease Inhibitor Research: Acts as a component in the design and development of enzyme inhibitors targeting proteases, where the threonine scaffold is often relevant.
• Bioconjugation & Labeling: Employed in the preparation of modified peptides for bioconjugation, diagnostic probes, or drug delivery systems.
• Chemical Biology & Tool Compound Synthesis: Integral for creating specialized amino acid analogs used to study protein function, structure-activity relationships (SAR), and metabolic pathways.
• Academic & Industrial R&D: A valuable reagent for methodological development in asymmetric synthesis and for exploring new chemical entities in life sciences research.

Basic Information

Product Name	H-D-Allo-Thr-Ome Hcl
CAS No.	60538-18-3
Molecular Formula	C5H12ClNO3
Molecular Weight	169.61 g/mol
Synonyms	H-D-allo-Thr-OMe hydrochloride; D-allo-Threonine methyl ester hydrochloride; Methyl (2R,3S)-2-amino-3-hydroxybutanoate hydrochloride; (2R,3S)-2-Amino-3-hydroxybutyric acid methyl ester hydrochloride; D-allo-Thr-OMe·HCl; allo-D-Threonine methyl ester HCl; H-D-aThr-OMe·HCl; (R,S)-allo-Threonine methyl ester hydrochloride
EINECS	Contact for details

Quality Control

Our H-D-Allo-Thr-Ome Hcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification and impurity profiling, to ensure it meets the high standards required for research and pharmaceutical applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% de
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.