Description

Methyl (1S,2R,3R,8S)-4-Aminocubane-1-Carboxylate Hydrochloride is a high-purity, synthetically challenging cubane derivative, prized for its unique three-dimensional cage structure and functional handles for further chemical elaboration. This compound matters as a sophisticated building block in advanced pharmaceutical research, enabling the development of novel drug candidates with potentially enhanced metabolic stability and bioavailability. It is primarily needed by medicinal chemistry and process R&D teams in pharmaceutical and biotechnology companies, as well as by academic researchers exploring new chemical spaces and structure-activity relationships.

Application

• Pharmaceutical Intermediate: Serves as a key chiral precursor for the synthesis of novel bioactive molecules and drug candidates, particularly those targeting central nervous system (CNS) disorders.
• Medicinal Chemistry Research: Used as a rigid, high-strain scaffold to probe protein-ligand interactions and improve the pharmacokinetic profiles of lead compounds.
• Chemical Biology Probe Development: Employed in the design and synthesis of molecular probes to study enzyme mechanisms and biological pathways due to its unique geometry.
• Advanced Materials Synthesis: Acts as a building block for creating novel polymers or energetic materials with specialized properties derived from the cubane core's high density and strain energy.
• Process Chemistry & Scale-Up: Utilized in route development and optimization studies for the commercial-scale production of complex target molecules.

Basic Information

Product Name	Methyl (1S,2R,3R,8S)-4-Aminocubane-1-Carboxylate Hydrochloride
CAS No.	60462-23-9
Molecular Formula	C11H15NO2·HCl
Molecular Weight	229.70 g/mol (Free base: 193.24 g/mol)
Synonyms	Methyl 4-aminocubane-1-carboxylate hydrochloride; (1S,2R,3R,8S)-Methyl 4-aminopentacyclo[4.2.0.02,5.03,8.04,7]octane-1-carboxylate hydrochloride; 4-Aminocubane-1-carboxylic acid methyl ester hydrochloride; Cubane-1-carboxylic acid, 4-amino-, methyl ester, hydrochloride, (1S,2R,3R,8S)-; Methyl 4-aminocubane-1-carboxylate HCl; Aminocubane methyl ester hydrochloride
EINECS	Contact for details

Quality Control

Our Methyl (1S,2R,3R,8S)-4-Aminocubane-1-Carboxylate Hydrochloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for demanding research applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity (typically ≥95% by HPLC), chiral purity, and impurity profiles. We adhere to relevant standards for fine chemical intermediates, and custom synthesis and purification to meet specific client specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.