Description

Benzo(A)Pyrene 11,12-Oxide is a critical metabolite and reference standard of the potent environmental carcinogen Benzo[a]pyrene. This compound is essential for researchers and quality control laboratories studying the metabolic activation pathways of polycyclic aromatic hydrocarbons (PAHs) and their associated DNA adduct formation. It is primarily used in analytical chemistry, toxicology research, and environmental monitoring to calibrate instruments and validate analytical methods for detecting and quantifying carcinogenic metabolites.

Application

• Analytical Reference Standard: Used as a high-purity calibrant in Gas Chromatography (GC), Liquid Chromatography (LC), and Mass Spectrometry (MS) for method development and validation.
• Toxicology & Metabolic Studies: A vital reagent for in vitro and in vivo research investigating the metabolic activation, detoxification, and genotoxic mechanisms of Benzo[a]pyrene.
• Biomarker Research: Employed in studies aiming to identify and quantify specific DNA adducts formed by PAH metabolites, serving as biomarkers of exposure and effect.
• Environmental Analysis: Supports the development of sensitive assays for monitoring PAH metabolites in environmental samples and biological matrices.
• Pharmaceutical Impurity Profiling: Used in impurity identification and method development where PAH contamination is a concern in drug substances or excipients.
• Chemical Carcinogenesis Research: A key compound for mechanistic studies on chemical carcinogenesis, enabling a deeper understanding of cancer etiology related to environmental pollutants.

Basic Information

Product Name	Benzo(A)Pyrene 11,12-Oxide
CAS No.	60448-19-3
Molecular Formula	C₂₀H₁₂O
Molecular Weight	268.31 g/mol
Synonyms	Benzo[a]pyrene 11,12-oxide; 11,12-Epoxy-11,12-dihydrobenzo[a]pyrene; BP 11,12-oxide; Benzo(a)pyrene 11,12-epoxide; 11,12-Oxidebenzo[a]pyrene; B[a]P 11,12-oxide; (±)-Benzo[a]pyrene 11,12-oxide
EINECS	Contact for details

Quality Control

Every batch of Benzo(A)Pyrene 11,12-Oxide is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure identity, purity, and stability, meeting the stringent requirements for research and analytical standards. A detailed Certificate of Analysis (COA) is supplied with each shipment, documenting results from techniques such as HPLC, GC-MS, and NMR. Our quality commitment supports compliance with relevant research and Good Laboratory Practice (GLP) standards.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere. Allow the container to reach room temperature in a desiccator before opening to prevent condensation. Store away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	Off-white to pale yellow solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	≤ 5.0% total
Solubility	Soluble in DMSO, Acetone

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.