Description

3,3-Dimethylspiro[Cyclopropane-1,1'-[1H]Indene]-2-Carboxylic Acid is a specialized spirocyclic carboxylic acid derivative that serves as a high-value synthetic intermediate. Its unique fused ring structure makes it a critical building block for constructing complex molecular architectures in advanced organic synthesis. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the creation of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders or possessing spirocyclic pharmacophores.
• Agrochemical Research: Used in developing new generations of herbicides, fungicides, or insecticides with unique modes of action derived from its constrained geometry.
• Material Science: Serves as a monomer or functional additive in the production of specialty polymers and advanced organic electronic materials.
• Organic Synthesis Building Block: Employed in complex multi-step syntheses, including cycloaddition reactions and the construction of sterically hindered, three-dimensional molecular scaffolds.
• Ligand and Catalyst Development: Utilized to create novel chiral ligands or organocatalysts for asymmetric synthesis applications.
• Chemical Biology Probe Synthesis: Acts as a core structure for developing molecular probes to study biological pathways and protein functions.

Basic Information

Product Name	3,3-Dimethylspiro[Cyclopropane-1,1'-[1H]Indene]-2-Carboxylic Acid
CAS No.	60424-44-4
Molecular Formula	C14H14O2
Molecular Weight	214.26 g/mol
Synonyms	3,3-Dimethylspiro[cyclopropane-1,1'-indene]-2-carboxylic acid; 1H-Indene-1-carboxylic acid, 2,3-dihydro-3,3-dimethylspiro[cyclopropane-1,1'-(1H)-indene]-2'-carboxylic acid; Spiro[cyclopropane-1,1'-indene]-2-carboxylic acid, 3,3-dimethyl-; 3,3-Dimethyl-1,1a,2,7b-tetrahydro-1H-cyclopropa[a]naphthalene-1-carboxylic acid
EINECS	Contact for details

Quality Control

Our 3,3-Dimethylspiro[Cyclopropane-1,1'-[1H]Indene]-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with agreed specifications. Our quality commitment supports applications in cGMP environments and research requiring the highest material integrity.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider inert gas purging to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.