Description

o-(4-Aminooxybutyl)Hydroxylamine is a specialized bifunctional organic compound featuring both aminooxy and hydroxylamine functional groups on a butyl chain. This unique structure makes it a valuable versatile linker and building block in advanced chemical synthesis, particularly for the formation of stable oxime bonds. It is primarily utilized by pharmaceutical researchers, bioconjugation specialists, and material scientists developing targeted drug delivery systems, diagnostic reagents, and functionalized polymers.

Application

• Bioconjugation and ADC Development: A critical reagent for site-specific conjugation of drugs, toxins, or fluorescent dyes to antibodies, proteins, or peptides via oxime ligation, enabling the creation of stable antibody-drug conjugates (ADCs) and diagnostic probes.
• Polymer and Material Science: Serves as a functional monomer or cross-linking agent for synthesizing smart hydrogels, surface-modified nanoparticles, and stimuli-responsive polymers with tailored properties.
• Organic Synthesis Intermediate: Used as a key building block in the synthesis of complex molecules, heterocycles, and novel chemical entities for medicinal chemistry and agrochemical research.
• Surface Functionalization: Employed to introduce aminooxy groups onto solid supports, chips, or beads for immobilizing carbonyl-containing biomolecules in biosensor and microarray technologies.
• Protein and Peptide Modification: Facilitates the selective modification of ketone or aldehyde-tagged proteins for studying protein function, interaction, and localization.

Basic Information

Item	Detail
Product Name	o-(4-Aminooxybutyl)Hydroxylamine
CAS No.	60302-18-3
Molecular Formula	C₄H₁₂N₂O₂
Molecular Weight	120.15 g/mol
Synonyms	4-(Aminooxy)butylhydroxylamine; O-(4-Aminooxybutyl)hydroxylamine; 4-(Aminooxy)-1-butylhydroxylamine; N-(4-Aminobutoxy)hydroxylamine; Amino-PEG4-alcohol-amine (related); AOA linker; Aminooxybutyl hydroxylamine; Butane-1,4-diol, 1-aminooxy-4-hydroxy (derivative)
EINECS	Contact for details

Quality Control

Our o-(4-Aminooxybutyl)Hydroxylamine is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and KF titration for water content, to ensure it meets the high standards required for research and development. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.