Description

Thp-Peg4 is a heterobifunctional polyethylene glycol (PEG) derivative featuring a tetrahydropyranyl (THP) protecting group. This compound is a crucial intermediate in organic synthesis and bioconjugation, valued for its solubility enhancement and orthogonal reactivity. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors for developing novel therapeutics, drug delivery systems, and functional polymers.

Application

• Pharmaceutical Linker Chemistry: Serves as a versatile spacer and linker in the synthesis of antibody-drug conjugates (ADCs), peptide-drug conjugates, and other targeted therapeutics.
• Polymer Modification: Used to introduce PEG chains into polymers or small molecules to improve hydrophilicity, reduce immunogenicity, and enhance pharmacokinetic properties.
• Protecting Group Strategy: The THP group provides a robust yet selectively removable protecting group for alcohols in complex multi-step organic syntheses.
• Bioconjugation Reagent: Acts as a heterobifunctional crosslinker for coupling biomolecules (e.g., proteins, peptides) with other functional entities like drugs, dyes, or solid surfaces.
• Material Science: Employed in the surface functionalization of nanoparticles and biomaterials to create stealth coatings or introduce specific reactive handles.
• Research & Development: A key building block in academic and industrial R&D for exploring new chemical biology tools and prodrug strategies.

Basic Information

Product Name	Thp-Peg4
CAS No.	60221-37-6
Molecular Formula	C19H36O8
Molecular Weight	392.49 g/mol
Synonyms	2,5,8,11-Tetraoxatridecan-13-yl 3,4-dihydro-2H-pyran-2-yl ether; Tetraethylene glycol monothp ether; THP-PEG4-OH; THP-(OCH2CH2)4-OH; 13-(Tetrahydro-2H-pyran-2-yloxy)-2,5,8,11-tetraoxatridecane; 2-[2-[2-[2-(Tetrahydro-2H-pyran-2-yloxy)ethoxy]ethoxy]ethoxy]ethanol; THP-protected tetraethylene glycol
EINECS	Contact for details

Quality Control

Our Thp-Peg4 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and structural integrity. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). The product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions when possible.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.