Description

(+-)-Deoxyephedrine-D5-Hydrochloride is a stable isotope-labeled analog of deoxyephedrine, where five hydrogen atoms are replaced with deuterium. This compound is a critical internal standard and reference material for analytical methods, ensuring accurate quantification and method validation in complex matrices. It is primarily required by analytical laboratories, forensic science institutions, and pharmaceutical R&D departments engaged in pharmacokinetic studies, metabolism research, and regulatory compliance testing.

Application

• Analytical Reference Standard: Serves as a primary internal standard for the precise quantification of methamphetamine and related compounds in forensic and clinical toxicology using GC-MS or LC-MS/MS.
• Metabolic Studies: Used in pharmaceutical research to trace drug metabolism and identify metabolites due to its isotopic labeling, providing insights into biotransformation pathways.
• Method Development & Validation: Essential for developing, calibrating, and validating highly sensitive and specific analytical methods in compliance with regulatory guidelines (e.g., FDA, EMA).
• Forensic Analysis: Critical for the unambiguous identification and confirmation of controlled substances in seized materials, supporting legal proceedings.
• Quality Control: Employed in pharmaceutical quality control laboratories to ensure the accuracy and reliability of assays for related substances.
• Research Chemical: Utilized in academic and industrial research investigating the pharmacological properties and environmental fate of stimulant compounds.

Basic Information

Product Name	(+-)-Deoxyephedrine-D5-Hydrochloride
CAS No.	60124-81-4
Molecular Formula	C10H10D5ClN
Molecular Weight	187.74 g/mol (for monoisotopic mass)
Synonyms	Methamphetamine-d5 Hydrochloride; N-Methylamphetamine-d5 HCl; d,l-Deoxyephedrine-d5 Hydrochloride; (±)-Desoxyephedrine-d5 Hydrochloride; 1-Phenyl-2-methylaminopropane-d5 Hydrochloride; N,α-Dimethylbenzeneethanamine-d5 Hydrochloride; Deoxyephedrine-d5 HCl
EINECS	Contact for details

Quality Control

Every batch of (+-)-Deoxyephedrine-D5-Hydrochloride is manufactured and analyzed under strict quality management systems. The product undergoes rigorous testing to ensure high chemical purity, isotopic enrichment, and structural integrity, meeting the stringent requirements for certified reference materials. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing specifications for assay, isotopic purity, and related substances. Our quality commitment supports compliance in regulated analytical environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere after each use to prevent degradation. For long-term storage, consider storing desiccated at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Assay (HPLC)	≥ 98.0% (on anhydrous basis)
Isotopic Purity	≥ 98 atom % D
Chemical Purity (HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5% w/w
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.