Description

(2R,5S)-6β-Hydroxymethyl-10β-Methyl-2-(1-Methylvinyl)Spiro[4.5]Decan-8-One is a high-purity, stereochemically defined spirocyclic ketone compound that serves as a critical chiral building block and advanced pharmaceutical intermediate. Its complex, rigid molecular architecture is essential for imparting specific biological activity and stereochemical integrity in final active pharmaceutical ingredients (APIs). This compound is primarily needed by research institutions and pharmaceutical manufacturers engaged in the synthesis of novel therapeutic agents, particularly in areas requiring sophisticated chiral chemistry.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug candidates, especially steroids and terpenoid-derived therapeutics.
• Asymmetric Synthesis: Used as a starting material or intermediate in catalytic asymmetric reactions to construct molecules with high enantiomeric excess.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and the development of new chemical entities (NCEs) due to its unique spirocyclic scaffold.
• Process Chemistry Development: Serves as a reference standard and a critical material for scaling up and optimizing synthetic routes in pilot plants and commercial manufacturing.
• Fine Chemical Synthesis: Utilized in the production of other high-value, specialized fine chemicals and fragrances that require its specific stereochemistry.

Basic Information

Product Name	(2R,5S)-6β-Hydroxymethyl-10β-Methyl-2-(1-Methylvinyl)Spiro[4.5]Decan-8-One
CAS No.	60077-68-1
Molecular Formula	C15H24O2
Molecular Weight	236.35 g/mol
Synonyms	(2R,5S)-6-(Hydroxymethyl)-10-methyl-2-(1-methylvinyl)spiro[4.5]decan-8-one; 6β-Hydroxymethyl-10β-methyl-2-(1-methylvinyl)spiro[4.5]decan-8-one; Spiro[4.5]decan-8-one, 6-(hydroxymethyl)-10-methyl-2-(1-methylvinyl)-, (2R,5S)-; (2R,5S)-6-(Hydroxymethyl)-10-methyl-2-(prop-1-en-2-yl)spiro[4.5]decan-8-one; CAS 60077-68-1
EINECS	Contact for details

Quality Control

Our (2R,5S)-6β-Hydroxymethyl-10β-Methyl-2-(1-Methylvinyl)Spiro[4.5]Decan-8-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity and chemical identity verification, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if specified.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.