Description

(-)-trans-4 5-Bis(Iodomethyl)-2,2-Dimethyl-1 3-Dioxolane CAS NO 60046-17-5 is a high-purity, chiral building block characterized by its dioxolane ring and reactive iodomethyl functional groups. This compound is valued for its role in stereoselective synthesis, enabling the construction of complex molecular architectures with precise spatial control. It is primarily sought by research and development teams in the pharmaceutical and fine chemical industries for applications in medicinal chemistry and advanced material science.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in antiviral, anticancer, and neurological drug discovery programs.
• Asymmetric Synthesis: Utilized as a versatile precursor in stereocontrolled reactions, including nucleophilic substitutions and cyclizations, to introduce chiral centers.
• Ligand and Catalyst Development: Serves as a starting material for creating novel chiral ligands and organocatalysts used in enantioselective transformations.
• Material Science Research: Employed in the development of specialty polymers and advanced organic materials with specific optical or structural properties.
• Chemical Biology Probes: Used to synthesize labeled compounds or molecular probes for studying biological pathways and mechanisms.

Basic Information

Product Name	(-)-trans-4 5-Bis(Iodomethyl)-2,2-Dimethyl-1 3-Dioxolane
CAS No.	60046-17-5
Molecular Formula	C7H12I2O2
Molecular Weight	397.98 g/mol
Synonyms	(-)-trans-4,5-Bis(iodomethyl)-2,2-dimethyl-1,3-dioxolane; (4R,5R)-4,5-Bis(iodomethyl)-2,2-dimethyl-1,3-dioxolane; (R,R)-4,5-Bis(iodomethyl)-2,2-dimethyl-1,3-dioxolane; trans-4,5-Diiodomethyl-2,2-dimethyl-1,3-dioxolane; Chiral Dioxolane Iodide; 1,3-Dioxolane, 4,5-bis(iodomethyl)-2,2-dimethyl-, (4R,5R)-
EINECS	Contact for details

Quality Control

Our (-)-trans-4 5-Bis(Iodomethyl)-2,2-Dimethyl-1 3-Dioxolane is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for research and development applications. Certificates of Analysis (COA) detailing identity, purity, and enantiomeric excess are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is light-sensitive and should be handled under an inert atmosphere when appropriate to ensure long-term stability.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.