Description

Trizma Citrate Tribasic is a high-purity, organic buffer salt derived from tris(hydroxymethyl)aminomethane (Tris) and citric acid. It is essential for creating stable, biocompatible buffering systems with a defined pH range, crucial for maintaining the integrity of sensitive biochemical and pharmaceutical processes. This reagent is primarily needed by manufacturers and researchers in the life sciences, pharmaceutical development, and diagnostic kit production where precise pH control is non-negotiable.

Application

• Biochemical & Molecular Biology Buffers: A key component in electrophoresis running buffers (e.g., TAE, TBE modifications), cell culture media, and protein purification systems.
• Pharmaceutical Formulation: Used as an excipient and buffering agent in parenteral solutions, ophthalmic preparations, and topical creams to ensure stability and compatibility.
• Diagnostic Reagents: Serves as a stable buffer matrix in clinical diagnostic assays, enzyme-linked immunosorbent assays (ELISA), and point-of-care testing strips.
• Chromatography: Employed as a mobile phase modifier in ion-exchange and affinity chromatography to improve separation of biomolecules.
• Cosmetic & Personal Care: Acts as a pH adjuster and stabilizer in skincare formulations, helping to maintain product efficacy and skin tolerance.

Basic Information

Product Name	Trizma Citrate Tribasic
CAS No.	6986-91-0
Molecular Formula	C12H23NO7
Molecular Weight	293.31 g/mol
Synonyms	Tris Citrate; Trisodium Citrate Tris; Tris(hydroxymethyl)aminomethane Citrate; Trometamol Citrate; 2-Amino-2-(hydroxymethyl)-1,3-propanediol Citrate; Citric Acid Tris Salt; THAM Citrate; Trizma® Citrate (Sigma trade name)
EINECS	230-238-7

Quality Control

Our Trizma Citrate Tribasic is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for research and manufacturing. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Due to its hygroscopic nature, keep the container tightly sealed to prevent moisture absorption, which can affect purity and stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to standard
Assay (Titration)	≥ 98.0 %
pH (1% Solution)	To be specified per grade
Loss on Drying	≤ 2.0 %
Heavy Metals (as Pb)	≤ 20 ppm
Residue on Ignition	≤ 0.1 %
Chloride (Cl)	≤ 0.05 %
Sulfate (SO4)	≤ 0.05 %

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.