Description

n-T-Butylglycine Hydrochloride is a protected amino acid derivative of significant value in advanced organic synthesis. This compound serves as a crucial building block for the preparation of peptides and peptidomimetics, offering enhanced steric control and metabolic stability. It is primarily utilized by pharmaceutical researchers, fine chemical manufacturers, and academic institutions engaged in the development of novel therapeutic agents and bioactive molecules.

Application

• Pharmaceutical Intermediates: A key chiral synthon in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates.
• Peptide Synthesis: Used as a protected amino acid in solid-phase and solution-phase peptide synthesis to introduce the sterically hindered tert-butylglycine residue.
• Peptidomimetics Research: Essential for creating modified peptide structures with improved bioavailability and receptor selectivity.
• Bioconjugation: Employed in the design and synthesis of linker molecules for antibody-drug conjugates (ADCs) and other bioconjugates.
• Chemical Biology Probes: Serves as a component in the development of probes for studying enzyme mechanisms and protein-protein interactions.
• Catalyst and Ligand Development: Used to synthesize novel chiral ligands and organocatalysts for asymmetric synthesis.

Basic Information

Product Name	n-T-Butylglycine Hydrochloride
CAS No.	6939-23-7
Molecular Formula	C6H13NO2 • HCl
Molecular Weight	167.63 g/mol (Free base: 131.17 g/mol)
Synonyms	2-Amino-2,2-dimethylethanoic Acid Hydrochloride; (Aminomethyl)dimethylacetic Acid Hydrochloride; tert-Butylglycine HCl; 2-Amino-2-methylpropanoic Acid Hydrochloride (common misnomer); 2-Amino-isobutyric Acid Hydrochloride (common misnomer); H-Tle-OH • HCl; (CH3)3C-Gly-OH • HCl; NSC 3349
EINECS	Contact for details

Quality Control

Our n-T-Butylglycine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and residual solvent screening, to ensure it meets the stringent requirements for research and production. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider using a desiccator.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity	≥99.0% ee
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Chloride Content	Conforms to theoretical

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.