Description

3α,7α,12α-Tris[(Trimethylsilyl)Oxy]-5β-Cholan-24-Oic Acid Methyl Ester is a key protected derivative of cholic acid, a primary bile acid, widely utilized as a critical synthetic intermediate in pharmaceutical research and development. This compound is specifically designed to safeguard reactive hydroxyl groups during complex organic synthesis, enabling the targeted production of novel steroid-based therapeutics and fine chemicals. It is an essential material for researchers and manufacturers in the pharmaceutical, biotechnology, and advanced organic chemistry sectors who require high-purity, reliable building blocks for drug discovery and process chemistry.

Application

• Pharmaceutical Intermediate: A crucial protected precursor in the multi-step synthesis of bile acid analogs, steroid hormones, and other bioactive molecules.
• Drug Discovery & Development: Used in medicinal chemistry for the research and development of new therapeutic agents targeting metabolic and liver-related pathways.
• Biochemical Research: Serves as a standard or reagent in studies investigating bile acid metabolism, receptor interactions, and transport mechanisms.
• Fine Chemical Synthesis: Employed in the production of specialized chiral compounds and complex organic molecules requiring selective protection strategies.
• Reference Standard: Can be utilized as a high-purity analytical reference material in quality control laboratories for method development and validation.

Basic Information

Product Name	3α,7α,12α-Tris[(Trimethylsilyl)Oxy]-5β-Cholan-24-Oic Acid Methyl Ester
CAS No.	6818-43-5
Molecular Formula	C33H62O5Si3
Molecular Weight	623.10 g/mol
Synonyms	Methyl 3α,7α,12α-tris(trimethylsilyloxy)-5β-cholan-24-oate; Methyl 3,7,12-Tris-O-(trimethylsilyl)cholate; Cholic Acid Methyl Ester Tris(trimethylsilyl) Ether; TMS-Cholic Acid Methyl Ester; 5β-Cholan-24-oic Acid, 3α,7α,12α-tris[(trimethylsilyl)oxy]-, Methyl Ester; Tris-O-trimethylsilyl Methyl Cholate
EINECS	Contact for details

Quality Control

Our 3α,7α,12α-Tris[(Trimethylsilyl)Oxy]-5β-Cholan-24-Oic Acid Methyl Ester is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and specific tests for residual solvents and moisture. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research or manufacturing specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.