Description

Folate Monoglutamate is the fundamental, single-glutamate form of Vitamin B9, a critical cofactor in one-carbon metabolism for nucleotide synthesis and amino acid interconversion. Its high purity and defined chemical structure make it an essential reference standard and a key ingredient for precise nutritional and pharmaceutical formulations. This compound is primarily required by manufacturers in the pharmaceutical, nutraceutical, and research sectors for producing high-grade supplements, clinical research materials, and analytical standards.

Application

• Pharmaceutical Reference Standard: Used as a primary chemical reference material (CRM) for the calibration and validation of analytical methods, including HPLC and microbiological assays, in quality control laboratories.
• Nutraceutical & Dietary Supplementation: Serves as a direct, bioavailable source of folic acid in premium-grade vitamin supplements, prenatal vitamins, and clinical nutrition products.
• Biochemical Research: Employed in cell culture media and as a substrate or inhibitor in enzymatic studies focused on folate metabolism and related pathways.
• Food Fortification Premixes: Incorporated into specialized premixes for the targeted fortification of staple foods, such as cereals and flour, to address public health nutritional deficiencies.
• Diagnostic Reagent Manufacturing: Utilized in the production of diagnostic kits and reagents for clinical tests measuring folate levels in serum or whole blood.

Basic Information

Product Name	Folate Monoglutamate
CAS No.	6807-82-5
Molecular Formula	C19H19N7O6
Molecular Weight	441.40 g/mol
Synonyms	Folic Acid Monoglutamate; Pteroylmonoglutamic Acid; Vitamin B9 Monoglutamate; N-[4-[[(2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic Acid; PGA; Folacin; Pteroyl-L-glutamic Acid
EINECS	229-862-4

Quality Control

Our Folate Monoglutamate is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including identification, purity assay, and impurity profiling, to ensure it meets stringent specifications suitable for pharmaceutical and nutritional applications. Certificates of Analysis (COA) detailing all test results are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	Yellow to orange, crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water (Karl Fischer)	≤ 8.5%
Residue on Ignition	≤ 0.3%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.