Description

2-O,3-O,4-O,5-O,6-o-Pentakis(Trimethylsilyl)-D-Mannose is a fully protected derivative of D-mannose, where all hydroxyl groups are silylated with trimethylsilyl (TMS) groups. This chemical modification is critical for its role as a key synthetic intermediate, providing enhanced solubility in organic solvents and protecting reactive sites during complex glycosylation and oligosaccharide synthesis. It is an essential building block for researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors who require high-purity, protected sugar intermediates for the development of novel therapeutics, diagnostics, and specialty carbohydrates.

Application

• Pharmaceutical Intermediate: Serves as a protected precursor in the multi-step synthesis of complex carbohydrate-based drugs, glycoconjugates, and active pharmaceutical ingredients (APIs).
• Glycochemistry Research: A fundamental reagent for academic and industrial research in glycoscience, enabling the study and construction of specific glycosidic linkages and oligosaccharide structures.
• Oligosaccharide & Glycopolymer Synthesis: Used in the controlled, sequential assembly of oligosaccharides and the creation of synthetic glycopolymers with tailored biological functions.
• Diagnostic Reagent Development: Employed in the production of carbohydrate antigens, probes, and labeling reagents for diagnostic assays and imaging.
• Chemical Biology Tool: Facilitates the synthesis of carbohydrate mimetics and inhibitors for probing biological pathways and enzyme functions.
• Specialty Materials: Acts as a monomer or modifier in the development of advanced biomaterials, hydrogels, and surface coatings with specific carbohydrate functionalities.

Basic Information

Product Name	2-O,3-O,4-O,5-O,6-o-Pentakis(Trimethylsilyl)-D-Mannose
CAS No.	6736-99-8
Molecular Formula	C23H54O6Si5
Molecular Weight	579.15 g/mol
Synonyms	D-Mannose, pentakis-O-(trimethylsilyl)-; Pentakis-O-trimethylsilyl-D-mannose; 1,2,3,4,5,6-Penta-O-trimethylsilyl-D-mannose; D-Mannose, penta-O-(trimethylsilyl)-; Penta-O-trimethylsilylmannose; TMS-Mannose; Fully Silylated D-Mannose; Mannose Penta-TMS Ether
EINECS	Contact for details

Quality Control

Our 2-O,3-O,4-O,5-O,6-o-Pentakis(Trimethylsilyl)-D-Mannose is manufactured under controlled conditions to ensure batch-to-batch consistency and high chemical purity. Each lot undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to confirm identity, purity, and the absence of critical impurities. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We adhere to a quality management system to support research and cGMP-grade manufacturing requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to prevent hydrolysis and maintain stability. Keep away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.