Description

2-[2-(2-Aminoethoxy)Ethoxy]Ethanol is a versatile amino-terminated polyether glycol, also known as a PEG-amine derivative. This compound is valued for its bifunctional nature, featuring a hydrophilic polyether backbone and a reactive primary amine group, making it an essential building block for chemical synthesis. It is primarily used in the pharmaceutical, biotechnology, and specialty polymer industries as a linker, spacer, or hydrophilic modifier. Its ability to impart water solubility and biocompatibility is critical for advanced applications.

Application

• Pharmaceutical Intermediates: Used as a key starting material or linker in the synthesis of active pharmaceutical ingredients (APIs), prodrugs, and antibody-drug conjugates (ADCs).
• Bioconjugation & PEGylation: Serves as a PEGylation reagent to modify proteins, peptides, and oligonucleotides, enhancing their stability, solubility, and circulation time in vivo.
• Polymer Chemistry: Acts as a monomer or chain extender in the production of polyurethanes, polyamides, and other specialty polymers, introducing hydrophilic and functional properties.
• Surface Modification: Employed to functionalize nanoparticles, quantum dots, and diagnostic assay surfaces to improve biocompatibility and reduce non-specific binding.
• Crosslinking Agent: Utilized in the formulation of hydrogels, coatings, and adhesives where a hydrophilic, amine-reactive crosslinker is required.
• Research & Development: A valuable tool in chemical biology and materials science research for creating novel functionalized molecules and materials.

Basic Information

Product Name	2-[2-(2-Aminoethoxy)Ethoxy]Ethanol
CAS No.	6338-55-2
Molecular Formula	C6H15NO3
Molecular Weight	149.19 g/mol
Synonyms	2,2'-(Ethylenedioxy)bis(ethylamine) diethanolate; 2,2'-(Ethylenedioxy)diethylamine; Amino-PEG2-alcohol; 3,6-Dioxa-1,8-octanediamine; 8-Amino-3,6-dioxaoctan-1-ol; O-(2-Aminoethyl)-O'-(2-hydroxyethyl)diethylene glycol; JEFFAMINE® XTJ-504; Polyoxyethylene (2) 2-aminoethyl ether
EINECS	228-722-7

Quality Control

Our 2-[2-(2-Aminoethoxy)Ethoxy]Ethanol is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing to ensure high purity and consistency, meeting the stringent requirements for pharmaceutical and research applications. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting key parameters such as assay, identity, and impurity profiles. We support compliance with relevant regulatory frameworks, including REACH and cGMP where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). To prevent degradation and maintain product integrity, containers must be kept tightly sealed after opening and consideration should be given to storage under an inert atmosphere for long-term preservation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Refractive Index (n20D)	1.458 - 1.462
Density (20°C)	1.05 - 1.10 g/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.