Description

Trimethylphosphoramide is a versatile organophosphorus compound with significant utility as a polar aprotic solvent and a key intermediate in organic synthesis. Its unique chemical structure makes it valuable for applications requiring a strong, non-nucleophilic base and a high-boiling reaction medium. This product is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries seeking reliable, high-purity reagents for complex synthetic pathways.

Application

• Pharmaceutical Intermediate: Used in the synthesis of active pharmaceutical ingredients (APIs), particularly in reactions requiring deprotonation or as a solvent for high-temperature transformations.
• Agrochemical Synthesis: Serves as a building block or catalyst in the production of advanced pesticides, herbicides, and plant growth regulators.
• Polymer Chemistry: Acts as a solvent or additive in polymerization processes and in the manufacture of specialty polymers and resins.
• Lithium-Ion Battery Electrolytes: Investigated as a potential component or additive in electrolyte formulations due to its thermal stability and solvating properties.
• Chemical Research & Development: A valuable reagent in academic and industrial R&D for exploring new synthetic methodologies, including organometallic chemistry and catalysis.
• Gas Treating Agent: Utilized in processes for the selective removal of acidic gases, such as carbon dioxide or hydrogen sulfide, from industrial streams.

Basic Information

Product Name	Trimethylphosphoramide
CAS No.	6326-72-3
Molecular Formula	C3H12N3OP
Molecular Weight	137.12 g/mol
Synonyms	Hexamethylphosphoric Triamide (HMPA); Hexamethylphosphoramide; Tris(dimethylamino)phosphine Oxide; Phosphoric Tris(dimethylamide); HMPT; Tris(N,N-dimethylamino)phosphine Oxide; ENT 50882; NSC 17787
EINECS	228-687-7

Quality Control

Our Trimethylphosphoramide is produced under stringent quality management systems to ensure batch-to-batch consistency and high purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as assay, identity, and impurity profiles. We adhere to relevant industry standards and can provide material tailored to specific customer requirements, including research and technical grades.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed to prevent absorption of atmospheric moisture. Keep away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Refractive Index (n20D)	1.457 - 1.461
Density (20°C)	1.02 - 1.03 g/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.