Description

(1R,2R,3S,4S)-3-Carbamoylbicyclo[2.2.1]Heptane-2-Carboxylic Acid is a high-purity, stereochemically defined bicyclic compound that serves as a critical chiral building block and intermediate in advanced organic synthesis. Its rigid, functionalized norbornane skeleton makes it a valuable scaffold for developing novel pharmaceuticals and fine chemicals with specific three-dimensional properties. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical industry for applications in medicinal chemistry, process development, and the synthesis of complex active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new therapeutic agents, particularly in central nervous system (CNS) and antiviral drug discovery.
• Medicinal Chemistry Scaffold: Used as a constrained, functionalized core structure for constructing compound libraries in structure-activity relationship (SAR) studies.
• Asymmetric Synthesis: Employed as a precursor or auxiliary in catalytic asymmetric reactions to induce chirality in target molecules.
• Process Chemistry: Serves as a starting material or intermediate in the scale-up and optimization of synthetic routes for complex molecules under Good Manufacturing Practice (GMP) conditions.
• Chemical Biology Probe Development: Utilized in the design and synthesis of molecular probes to study biological pathways and protein-ligand interactions.
• Academic & Industrial Research: A valuable reagent for methodological studies in organic synthesis and the exploration of new chemical space.

Basic Information

Item	Detail
Product Name	(1R,2R,3S,4S)-3-Carbamoylbicyclo[2.2.1]Heptane-2-Carboxylic Acid
CAS No.	6251-87-2
Molecular Formula	C9H13NO3
Molecular Weight	183.20 g/mol
Synonyms	(1R,2R,3S,4S)-3-Carbamoylbicyclo[2.2.1]heptane-2-carboxylic acid; (1R,2R,3S,4S)-3-Carbamoylnorbornane-2-carboxylic acid; endo-3-Carbamoylbicyclo[2.2.1]heptane-2-carboxylic acid (specific stereoisomer); (1R,2R,3S,4S)-2-Carboxybicyclo[2.2.1]heptane-3-carboxamide; Bicyclo[2.2.1]heptane-2-carboxylic acid, 3-carbamoyl-, (1R,2R,3S,4S)-; Chiral Norbornane Derivative
EINECS	Contact for details

Quality Control

Our (1R,2R,3S,4S)-3-Carbamoylbicyclo[2.2.1]Heptane-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and stereochemical integrity, meeting the stringent requirements for pharmaceutical research and development. Certificates of Analysis (COA) detailing results from HPLC, chiral analysis, NMR, and other relevant tests are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.