Description

17Alpha-Estradiol Hemihydrate Vetranal is a high-purity analytical reference standard of the estrogenic steroid hormone. This compound is critical for ensuring the accuracy and reliability of analytical methods in research and quality control laboratories. It is primarily required by pharmaceutical R&D, veterinary medicine manufacturers, and analytical service providers for use as a certified reference material in method validation, calibration, and impurity profiling.

Application

• Pharmaceutical Reference Standard: Used as a primary standard for the quantitative and qualitative analysis of estradiol-based active pharmaceutical ingredients (APIs) and finished products.
• Veterinary Pharmaceutical Development: Serves as a key analytical standard in the research, formulation, and quality control of veterinary hormone treatments.
• Method Validation & Calibration: Essential for validating HPLC, GC-MS, and other chromatographic assays in compliance with ICH, USP, and EP guidelines.
• Impurity Identification and Quantification: Employed as a known impurity or degradation product marker in stability studies and specification setting.
• Clinical & Biomedical Research: Utilized as a precise reagent in endocrine and metabolic pathway studies.
• Quality Control Laboratory: Provides a benchmark for in-house testing to ensure batch-to-batch consistency and regulatory compliance.

Basic Information

Product Name	17Alpha-Estradiol Hemihydrate Vetranal
CAS No.	6045-52-9
Molecular Formula	C18H24O2 • ½ H2O
Molecular Weight	275.35 g/mol (anhydrous basis)
Synonyms	17α-Estradiol Hemihydrate; 1,3,5(10)-Estratriene-3,17α-diol Hemihydrate; α-Estradiol Hemihydrate; 17-epi-Estradiol Hemihydrate; Vetranal™ (analytical standard grade); Estra-1,3,5(10)-triene-3,17α-diol Hemihydrate; 17α-Hydroxyestra-1,3,5(10)-trien-3-ol Hemihydrate
EINECS	Contact for details

Quality Control

Our 17Alpha-Estradiol Hemihydrate Vetranal is manufactured and handled under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including identity confirmation by IR and NMR, purity assay by HPLC, and control of related substances and residual solvents. A Certificate of Analysis (COA) is provided, detailing all test results against stringent in-house specifications suitable for use as an analytical reference material.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; ensure the container is sealed tightly after each use to minimize exposure to atmospheric moisture and light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0% (on anhydrous basis)
Water Content (KF)	2.5% - 4.0% (theoretical hemihydrate: ~3.27%)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.