Description

Chlorogenic Acid Hemihydrate is a naturally occurring polyphenolic compound and a key ester of caffeic acid and quinic acid. It serves as a powerful antioxidant and bioactive ingredient, valued for its role in modulating metabolic pathways and scavenging free radicals. This high-purity material is essential for manufacturers in the nutraceutical, pharmaceutical, and cosmetic industries seeking standardized botanical extracts.

Application

• Nutraceutical & Dietary Supplements: A core active ingredient in formulations targeting weight management, blood sugar support, and antioxidant defense systems.
• Pharmaceutical Intermediates: Used in research and development of drugs for metabolic disorders, including diabetes and cardiovascular health.
• Cosmetic & Personal Care: Incorporated into anti-aging serums, creams, and lotions for its skin-brightening and protective properties against environmental oxidative stress.
• Food & Beverage Fortification: Acts as a natural preservative and functional additive to enhance the health profile of beverages and food products.
• Standard Reference Material: Serves as an analytical standard in quality control laboratories for the assay of green coffee bean extract, honeysuckle, and other botanicals.
• Research & Development: Utilized in biochemical and pharmacological studies investigating anti-inflammatory, hepatoprotective, and neuroprotective effects.

Basic Information

Product Name	Chlorogenic Acid Hemihydrate
CAS No.	6001-76-9
Molecular Formula	C₁₆H₁₈O₉ • ½H₂O
Molecular Weight	363.31 g/mol (Anhydrous basis: 354.31)
Synonyms	3-Caffeoylquinic Acid; 3-O-Caffeoylquinic Acid; Heriguard; CGA; 3-CQA; (1S,3R,4R,5R)-3-[[(2E)-3-(3,4-Dihydroxyphenyl)prop-2-enoyl]oxy]-1,4,5-trihydroxycyclohexanecarboxylic acid; Chlorogensäure (German); Acide chlorogénique (French)
EINECS	227-850-8

Quality Control

Our Chlorogenic Acid Hemihydrate is produced under strict quality management systems. Each batch is tested to ensure it meets stringent specifications for identity, purity, and potency, aligning with industry standards for botanical extracts. Certificates of Analysis (COA) documenting comprehensive HPLC assay, residual solvents, and heavy metals are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This material is easily oxidized and should be handled under an inert atmosphere when appropriate to maintain potency.

Specification

Item	Specification
Appearance	White to light yellow crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0% (on anhydrous basis)
Water Content (KF)	2.0% - 4.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.