Description

4-Iodophenetole is a versatile aromatic ether building block characterized by the presence of both an iodine substituent and an ethoxy group on the benzene ring. This unique structure makes it a valuable intermediate in advanced organic synthesis, particularly for cross-coupling reactions and the construction of complex molecules. It is primarily utilized by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors for developing active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those requiring aryl-ether or aryl-iodide motifs for further functionalization.
• Agrochemical Synthesis: Used in the research and production of herbicides, fungicides, and other crop protection agents where its halogenated aromatic core is integral to biological activity.
• Material Science Research: Acts as a monomer or building block for creating novel polymers, liquid crystals, and organic electronic materials due to its polarizable iodine atom and ether linkage.
• Cross-Coupling Reactions: The iodine atom is an excellent leaving group in palladium-catalyzed reactions like Suzuki, Heck, and Sonogashira couplings, enabling efficient carbon-carbon bond formation.
• Chemical Research & Development: Employed in academic and industrial R&D labs as a standard reagent for methodological studies and the exploration of new synthetic pathways.
• Dye and Pigment Intermediate: Utilized in the synthesis of complex organic dyes and pigments, where the iodine can influence color properties and stability.

Basic Information

Item	Details
Product Name	4-Iodophenetole
CAS No.	699-08-1
Molecular Formula	C8H9IO
Molecular Weight	248.06 g/mol
Synonyms	1-Ethoxy-4-iodobenzene; p-Iodophenetole; 4-Ethoxyiodobenzene; Phenetole, p-iodo-; Iodophenetole; 4-Iodophenyl ethyl ether; (4-Iodophenoxy)ethane
EINECS	211-828-6

Quality Control

Our 4-Iodophenetole is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, prolonged exposure to direct light should be avoided.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	36 - 40 °C
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.