Description

1,2-Dichloro-4-Trifluoromethansulfonylbenzene is a high-value, multi-functional aromatic building block featuring both chloro and trifluoromethanesulfonyl (triflyl) substituents. This compound is critical for advanced synthesis, particularly in the development of active pharmaceutical ingredients (APIs) and specialty agrochemicals, where its unique electronic properties enable precise molecular modifications. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex, performance-oriented molecules.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel drug candidates, especially those requiring sulfonamide or aryl chloride functional groups for further coupling reactions (e.g., Suzuki, Buchwald-Hartwig amination).
• Agrochemical Active Ingredient Precursor: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethanesulfonyl group enhances biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis.
• Functional Material Synthesis: Employed in the development of organic electronic materials, such as semiconductors for OLEDs or OFETs, due to its electron-withdrawing characteristics.
• Cross-Coupling Reactions: The chlorine atoms provide excellent handles for palladium-catalyzed cross-coupling reactions to build complex biaryl and heteroaryl structures.
• Chemical Research & Development: A versatile reagent for exploring new synthetic methodologies and constructing molecular libraries for high-throughput screening.

Basic Information

Product Name	1,2-Dichloro-4-Trifluoromethansulfonylbenzene
CAS No.	672-55-9
Molecular Formula	C7H3Cl2F3O2S
Molecular Weight	278.06 g/mol
Synonyms	3,4-Dichlorophenyl trifluoromethyl sulfone; 1,2-Dichloro-4-(trifluoromethylsulfonyl)benzene; 3,4-Dichloro-α,α,α-trifluorobenzenemethanesulfonate; 3,4-Dichlorobenzotrifluoride sulfone; 3,4-Dichloro-α,α,α-trifluorotoluene-p-sulfone; 3,4-Dichlorophenyl triflyl; 3,4-Dichloro-α,α,α-trifluoromethyl phenyl sulfone
EINECS	Contact for details

Quality Control

Our 1,2-Dichloro-4-Trifluoromethansulfonylbenzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment. We support cGMP compliance for pharmaceutical applications and can tailor specifications to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. The container must be kept tightly closed to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.