Description

1-Ethoxy-2-Nitro-4-(Trifluoromethyl)Benzene is a high-purity aromatic intermediate featuring a nitro group and a trifluoromethyl substituent. This compound is valued for its role as a versatile building block in advanced organic synthesis, enabling the introduction of key functional groups into target molecules. It is primarily sought by R&D chemists and process development teams in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring a trifluoromethylphenyl moiety for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the nitro and trifluoromethyl groups contribute to biological activity.
• Material Science Research: Serves as a monomer or functionalization agent in the development of specialty polymers and liquid crystals.
• Dye and Pigment Intermediate: Employed in the synthesis of complex organic dyes and pigments, leveraging its nitro group for chromophore development.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) to create complex biaryl structures.
• Fluorine Chemistry Studies: A valuable compound for research focused on the incorporation and behavior of fluorine atoms in organic molecules.

Basic Information

Product Name	1-Ethoxy-2-Nitro-4-(Trifluoromethyl)Benzene
CAS No.	655-08-3
Molecular Formula	C9H8F3NO3
Molecular Weight	235.16 g/mol
Synonyms	2-Nitro-4-(trifluoromethyl)phenetole; 4-Ethoxy-3-nitrobenzotrifluoride; 1-Ethoxy-2-nitro-4-(trifluoromethyl)benzene; 2-Nitro-α,α,α-trifluoro-p-phenetole; Benzene, 1-ethoxy-2-nitro-4-(trifluoromethyl)-; 3-Nitro-4-ethoxybenzotrifluoride; p-Ethoxy-m-nitrobenzotrifluoride; 4-(Trifluoromethyl)-2-nitrophenetole
EINECS	211-486-8

Quality Control

Our 1-Ethoxy-2-Nitro-4-(Trifluoromethyl)Benzene is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications. We support cGMP standards for pharmaceutical applications and can provide regulatory support documentation as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.