Description

1,3-Dioxolane CAS NO 646-06-0 is a versatile heterocyclic acetal and a high-purity solvent with excellent solvating properties. Its primary value lies in its dual functionality as a reactive intermediate and a high-performance solvent, particularly in demanding chemical syntheses. This product is essential for manufacturers in the pharmaceutical, agrochemical, and specialty polymer industries seeking reliable, high-quality raw materials for complex processes.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of various active pharmaceutical ingredients (APIs), particularly where protected carbonyl groups are required.
• Specialty Solvent: Used as a high-purity, aprotic solvent for sensitive reactions, including Grignard reactions, lithiations, and polymerizations, due to its stability and low nucleophilicity.
• Polymer Chemistry: Serves as a monomer or co-monomer in the production of specialty polymers, polyacetals, and resins, contributing to specific material properties.
• Electrolyte Component: Employed as a solvent in advanced lithium-ion battery electrolytes, where its properties can enhance ionic conductivity and battery performance.
• Chemical Synthesis Protecting Group: Effectively protects aldehydes and ketones as their cyclic acetals during multi-step synthetic sequences.
• Agrochemical Formulation: Used as a solvent and carrier in the formulation of pesticides and herbicides.

Basic Information

Product Name	1,3-Dioxolane
CAS No.	646-06-0
Molecular Formula	C3H6O2
Molecular Weight	74.08 g/mol
Synonyms	1,3-Dioxacyclopentane; Ethylene glycol formal; Formaldehyde ethylene acetal; 1,3-Dioxolan; Ethylene formal; Glycol formal; Dioxolane; NSC 60526
EINECS	211-463-5

Quality Control

Our 1,3-Dioxolane is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive quality assurance, with testing typically including identity confirmation, assay (purity), water content, and specific impurity profiles. A Certificate of Analysis (COA) is supplied with each shipment, detailing all relevant specifications and test results. Our quality protocols are designed to meet the stringent requirements of cGMP and ISO standards for industrial and fine chemical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area away from heat sources and ignition points. Due to its highly volatile nature, containers must be kept tightly sealed when not in use to prevent evaporation and concentration of peroxides. Recommended storage temperature is 2-25°C. Store away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Clear, colorless liquid
Identification (IR)	Conforms
Assay (GC)	≥ 99.0%
Water Content (KF)	≤ 0.1%
Refractive Index (n20D)	1.397 - 1.401
Density (20°C)	1.060 - 1.070 g/mL
Boiling Point	74 - 75°C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.