Description

1-Iodo-2-Nitrobenzene is a versatile halogenated nitroaromatic compound that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring both an iodine substituent and a nitro group on the benzene ring, makes it a valuable precursor for constructing complex molecules through cross-coupling and nucleophilic substitution reactions. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries, enabling the development of new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of novel drug candidates.
• Agrochemical Synthesis: Used in the production of advanced pesticides, herbicides, and fungicides, leveraging its reactivity to create complex bioactive molecules.
• Ligand & Catalyst Preparation: Serves as a precursor for synthesizing specialized ligands and organometallic catalysts used in homogeneous catalysis.
• Material Science Research: Employed in the development of organic electronic materials, liquid crystals, and dyes due to its electron-withdrawing and heavy atom properties.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, and Sonogashira couplings to form biaryl and other complex structures.
• Nucleophilic Aromatic Substitution: The activated nitro group facilitates substitution reactions, allowing for the introduction of various amines and other nucleophiles.

Basic Information

Product Name	1-Iodo-2-Nitrobenzene
CAS No.	609-73-4
Molecular Formula	C6H4INO2
Molecular Weight	249.01 g/mol
Synonyms	2-Nitroiodobenzene; o-Iodonitrobenzene; 2-Nitro-1-iodobenzene; 1-Iodo-2-nitrobenzene; Iodonitrobenzene; (2-Nitrophenyl)iodide; Benzene, 1-iodo-2-nitro-; NSC 9235
EINECS	210-208-6

Quality Control

Our 1-Iodo-2-Nitrobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality commitment ensures the material meets the stringent requirements for research and cGMP manufacturing applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be amber glass or otherwise opaque.

Specification

Item	Specification
Appearance	Yellow to pale brown crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	52 - 56 °C
Heavy Metals	< 20 ppm
Residue on Ignition	< 0.1%
Related Substances (HPLC)	Total impurities < 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.