Description

6-Fluoro-4-(Trifluoromethyl)Quinoline-3-Carboxylic Acid is a high-value, multi-functional heterocyclic building block essential for advanced organic synthesis. Its unique fluorinated quinoline core structure makes it a critical intermediate for developing novel active pharmaceutical ingredients (APIs) and agrochemicals with enhanced properties. This compound is primarily sought by research and development chemists in the pharmaceutical, agrochemical, and specialty chemical industries for creating compounds with improved metabolic stability, bioavailability, and binding affinity.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential drug candidates, particularly in oncology, antiviral, and anti-inflammatory research, leveraging the fluorine and trifluoromethyl groups for bioactivity.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the fluorinated quinoline scaffold contributes to efficacy and environmental profile.
• Material Science Research: Serves as a building block for creating advanced organic electronic materials, such as OLED (Organic Light-Emitting Diode) components or fluorinated polymers.
• Ligand and Catalyst Development: The carboxylic acid and nitrogen heterocycle provide coordination sites for designing novel metal-organic complexes and catalysts.
• Fluorinated Compound Library: Essential for medicinal and combinatorial chemistry to build diverse libraries of fluorinated compounds for high-throughput screening.

Basic Information

Product Name	6-Fluoro-4-(Trifluoromethyl)Quinoline-3-Carboxylic Acid
CAS No.	596845-53-3
Molecular Formula	C11H5F4NO2
Molecular Weight	259.16 g/mol
Synonyms	6-Fluoro-4-(trifluoromethyl)-3-quinolinecarboxylic acid; 3-Quinolinecarboxylic acid, 6-fluoro-4-(trifluoromethyl)-; 6-Fluoro-4-trifluoromethylquinoline-3-carboxylic acid; 6-Fluoro-4-(trifluoromethyl)quinoline-3-carboxylate; 6-Fluoro-4-(trifluoromethyl)quinoline-3-carboxylic acid (CAS 596845-53-3)
EINECS	Contact for details

Quality Control

Our 6-Fluoro-4-(Trifluoromethyl)Quinoline-3-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent chemical identity. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with customer specifications and internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.