Description

2-Chloro-4-[4-(2-Methylquinolin-4-Yl)Piperazin-1-Yl]Quinazoline is a high-purity, advanced pharmaceutical intermediate of significant interest in modern medicinal chemistry. This compound matters as a key synthetic building block for the development of novel, targeted therapeutic agents, particularly in oncology and other disease areas. Pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers need this material for lead optimization and the synthesis of potent, selective kinase inhibitors.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel kinase inhibitor candidates for oncology research.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to optimize drug potency and selectivity.
• Biochemical Tool Compound: Serves as a reference standard or a starting point for developing proprietary assay reagents.
• Contract Manufacturing: Supplied to CDMOs for the scale-up and cGMP production of active pharmaceutical ingredients (APIs).
• Academic Research: Utilized in university and institutional labs for investigating new signaling pathways and therapeutic targets.

Basic Information

Product Name	2-Chloro-4-[4-(2-Methylquinolin-4-Yl)Piperazin-1-Yl]Quinazoline
CAS No.	591726-35-1
Molecular Formula	C22H20ClN5
Molecular Weight	389.88 g/mol
Synonyms	2-Chloro-4-(4-(2-methylquinolin-4-yl)piperazin-1-yl)quinazoline; 4-(4-(2-Methyl-4-quinolyl)-1-piperazinyl)-2-chloroquinazoline; 2-Chloro-4-[4-(2-methyl-4-quinolyl)-1-piperazinyl]quinazoline; 591726-35-1; UNII-9J6K9N8V4I; 9J6K9N8V4I; Quinazoline, 2-chloro-4-[4-(2-methyl-4-quinolyl)-1-piperazinyl]-; BDBM50111657; AKOS005258213
EINECS	Contact for details

Quality Control

Our 2-Chloro-4-[4-(2-Methylquinolin-4-Yl)Piperazin-1-Yl]Quinazoline is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles, typically determined by advanced analytical techniques like HPLC, NMR, and LC-MS. We support compliance with relevant guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.