Description

2-Bromo-4-(Trifluoromethyl)Quinoline is a high-value, multi-functional heterocyclic building block characterized by its bromine and trifluoromethyl substituents. This compound is essential for facilitating advanced cross-coupling reactions and introducing lipophilic, electron-withdrawing groups into target molecules. It is primarily sought by R&D chemists and process development teams in the pharmaceutical, agrochemical, and advanced materials sectors for the synthesis of novel active ingredients and functional compounds.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Material Science Research: Serves as a building block for creating organic electronic materials, such as ligands for OLEDs and charge-transport materials, due to its electron-deficient quinoline core.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for Suzuki, Stille, and Buchwald-Hartwig amination reactions, enabling rapid diversification of molecular libraries.
• Fluorine Chemistry: The CF3 group provides a metabolically stable and lipophilic moiety, making it valuable for medicinal chemistry programs aimed at improving drug potency and pharmacokinetic properties.

Basic Information

Product Name	2-Bromo-4-(Trifluoromethyl)Quinoline
CAS No.	590372-17-1
Molecular Formula	C10H5BrF3N
Molecular Weight	276.06 g/mol
Synonyms	4-(Trifluoromethyl)-2-bromoquinoline; 2-Bromo-4-trifluoromethylquinoline; Quinoline, 2-bromo-4-(trifluoromethyl)-; 590372-17-1; 2-Bromo-4-(trifluoromethyl)quinoline; 2-Bromo-4-(trifluoromethyl)chinolin
EINECS	Contact for details

Quality Control

Every batch of 2-Bromo-4-(Trifluoromethyl)Quinoline is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and batch-to-batch consistency suitable for sensitive R&D and scale-up processes. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥97.0%
Melting Point	Contact for details
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.