Description

1-(Mesitylsulfonyl)Piperidine-4-Carbohydrazide is a specialized organic building block featuring a piperidine core functionalized with both a mesitylsulfonyl protecting group and a reactive carbohydrazide moiety. This compound is valued for its role as a key intermediate in the synthesis of complex molecules, particularly in pharmaceutical research and development. It is primarily utilized by medicinal chemists and process development scientists working on novel active pharmaceutical ingredients (APIs), especially those targeting central nervous system (CNS) disorders and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of novel drug candidates, particularly for CNS-targeting therapies.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR).
• Process Chemistry Development: Serves as a starting material or advanced intermediate for scaling up API synthesis under Good Manufacturing Practice (GMP) conditions.
• Proteolysis Targeting Chimera (PROTAC) Development: The reactive hydrazide group can be leveraged to construct linkers for bifunctional degrader molecules.
• Chemical Biology Probe Synthesis: Useful for creating tool compounds to study biological pathways and protein function.
• Agrochemical Research: Potential intermediate in the development of new crop protection agents with specific biological activity.

Basic Information

Item	Details
Product Name	1-(Mesitylsulfonyl)Piperidine-4-Carbohydrazide
CAS No.	590357-03-2
Molecular Formula	C15H23N3O3S
Molecular Weight	325.42 g/mol
Synonyms	1-[(2,4,6-Trimethylphenyl)sulfonyl]-4-piperidinecarbohydrazide; 4-Hydrazinylcarbonyl-1-(2,4,6-trimethylbenzenesulfonyl)piperidine; Piperidine-4-carbohydrazide, 1-(mesitylsulfonyl)-; 1-Mesitylsulfonylpiperidine-4-carboxylic acid hydrazide; 590357-03-2; 1-(Mesitylsulfonyl)piperidine-4-carboxylic hydrazide
EINECS	Contact for details

Quality Control

Our 1-(Mesitylsulfonyl)Piperidine-4-Carbohydrazide is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and Mass Spectrometry. We provide comprehensive Certificates of Analysis (COA) detailing all specifications, ensuring traceability and compliance with research and development standards. Custom purity grades and analytical packages are available to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is easily oxidized; for long-term storage, consider keeping under an inert atmosphere (e.g., nitrogen or argon) to maintain stability. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.