Description

(R)-tert-Butyl 1-(3-Benzyl-7-Chloro-4-Oxo-3,4-Dihydroquinazolin-2-Yl)-2-Methylpropylcarbamate is a high-purity, chiral synthetic intermediate of significant importance in advanced pharmaceutical research and development. Its complex quinazolinone-based structure makes it a valuable building block for the synthesis of novel, biologically active compounds. This product is primarily targeted at R&D chemists and process development scientists in the pharmaceutical and biotechnology industries, particularly those working on kinase inhibitors and other targeted therapeutic agents. The compound is supplied with a guaranteed Certificate of Analysis to ensure batch-to-batch consistency and reliability for critical synthetic pathways.

Application

• Pharmaceutical Intermediate: Serves as a key chiral precursor in the multi-step synthesis of potential drug candidates, especially in oncology and anti-inflammatory research.
• Kinase Inhibitor Development: Used as a core scaffold or intermediate for constructing molecules designed to modulate kinase activity, a major target class in modern drug discovery.
• Process Chemistry & Scale-Up: Employed in route scouting and optimization studies for the commercial-scale production of active pharmaceutical ingredients (APIs).
• Chemical Biology Research: Utilized as a tool compound or a starting point for creating chemical probes to study specific biological pathways and protein functions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds for client projects.
• Academic Research: Used in university and institutional laboratories for methodological development in asymmetric synthesis and heterocyclic chemistry.

Basic Information

Product Name	(R)-tert-Butyl 1-(3-Benzyl-7-Chloro-4-Oxo-3,4-Dihydroquinazolin-2-Yl)-2-Methylpropylcarbamate
CAS No.	587881-33-2
Molecular Formula	C24H28ClN3O3
Molecular Weight	441.95 g/mol
Synonyms	Carbamic acid, N-[(1R)-1-[[(3-benzyl-7-chloro-4-oxo-3,4-dihydro-2-quinazolinyl)amino]carbonyl]-2-methylpropyl]-, 1,1-dimethylethyl ester; (R)-tert-Butyl (1-(3-benzyl-7-chloro-4-oxo-3,4-dihydroquinazolin-2-yl)-2-methylpropyl)carbamate; tert-Butyl N-[(1R)-1-[(3-benzyl-7-chloro-4-oxo-3H-quinazolin-2-yl)carbamoyl]-2-methyl-propyl]carbamate; BOC-Protected Quinazolinone Intermediate; (R)-Boc-Val-Quinazolinone Derivative.
EINECS	Contact for details

Quality Control

Every batch of (R)-tert-Butyl 1-(3-Benzyl-7-Chloro-4-Oxo-3,4-Dihydroquinazolin-2-Yl)-2-Methylpropylcarbamate is manufactured and controlled under a strict quality management system. Our products undergo rigorous analytical testing, including chiral HPLC, to ensure high enantiomeric purity and chemical identity, meeting the exacting standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to guarantee traceability and compliance with your internal quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥97.0%
Chiral Purity (Chiral HPLC)	≥98.0% ee
Loss on Drying	≤1.0%
Residue on Ignition	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.