Description

Benzene, 1-(Chloromethyl)-3-(Methylsulfonyl)- is a specialized aromatic compound featuring both a reactive chloromethyl group and a methylsulfonyl moiety, making it a valuable bifunctional building block in advanced organic synthesis. Its primary value lies in its utility as a key intermediate for constructing complex molecules, particularly in the development of pharmaceuticals and agrochemicals. This product is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries who require high-purity intermediates for constructing sulfone-containing scaffolds.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing sulfone or benzyl chloride pharmacophores.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides where the methylsulfonyl group enhances biological activity.
• Material Science Research: Acts as a monomer or cross-linking agent in the development of specialty polymers and advanced organic materials.
• Ligand and Catalyst Development: Employed in the creation of novel sulfone-based ligands for catalytic systems in asymmetric synthesis.
• Chemical Biology Probes: Useful for synthesizing molecular probes and tags due to its reactive chloromethyl handle for bioconjugation.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	Benzene, 1-(Chloromethyl)-3-(Methylsulfonyl)-
CAS No.	586373-70-8
Molecular Formula	C8H9ClO2S
Molecular Weight	204.67 g/mol
Synonyms	3-(Methylsulfonyl)benzyl Chloride; 1-(Chloromethyl)-3-(methylsulfonyl)benzene; (3-Methylsulfonylphenyl)methyl Chloride; m-(Methylsulfonyl)benzyl Chloride; α-Chloro-3-(methylsulfonyl)toluene; 3-Methylsulfonylbenzyl Chloride; 3-(Methylsulphonyl)benzyl Chloride; 1-Chloromethyl-3-methylsulfonylbenzene
EINECS	Contact for details

Quality Control

Our Benzene, 1-(Chloromethyl)-3-(Methylsulfonyl)- is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research and industrial use. All products undergo rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.