Description

(3S,4S)-4-[(1R)-Phenylethylamino-3-Methoxycarbonyl]-2,2,6,6-Tetramethylpiperidine-1-Oxyl Hydrochloride is a high-purity, chiral nitroxide radical compound primarily used as a spin label and probe in advanced research. Its value lies in its stable free radical character and defined stereochemistry, making it an essential tool for studying molecular dynamics and structure. This product is critical for researchers and developers in the fields of magnetic resonance spectroscopy (EPR/ESR), polymer science, biophysics, and pharmaceutical research, where precise molecular tagging is required.

Application

• Spin Labeling in EPR/ESR Spectroscopy: Used as a stable paramagnetic probe to investigate the structure, dynamics, and local environment of biomolecules, polymers, and materials.
• Biophysical Research: Tagging of proteins, nucleic acids, and membranes to study conformational changes, distances, and interactions via site-directed spin labeling (SDSL).
• Polymer Chemistry & Material Science: Acting as a radical trap or probe to study polymerization kinetics, polymer chain mobility, and degradation mechanisms.
• Pharmaceutical Development: Utilized in research for studying drug-membrane interactions, protein-ligand binding, and as a potential building block for novel therapeutics.
• Oxidation Catalysis: Serving as a catalyst or co-catalyst in selective oxidation reactions due to its nitroxyl radical functionality.
• Antioxidant Research: Investigation of radical scavenging activity and studies related to oxidative stress in biological systems.

Basic Information

Product Name	(3S,4S)-4-[(1R)-Phenylethylamino-3-Methoxycarbonyl]-2,2,6,6-Tetramethylpiperidine-1-Oxyl Hydrochloride
CAS No.	583827-06-9
Molecular Formula	C20H31ClN2O3
Molecular Weight	382.92 g/mol
Synonyms	4-[(1R)-1-Phenylethylamino]-3-methoxycarbonyl-2,2,6,6-tetramethylpiperidine-1-oxyl hydrochloride; (3S,4S)-4-[(1R)-1-Phenylethylamino]-3-(methoxycarbonyl)-2,2,6,6-tetramethylpiperidine-1-oxyl hydrochloride; Chiral TEMPO derivative hydrochloride; Nitroxyl radical spin label hydrochloride; 1-Oxyl-2,2,6,6-tetramethyl-4-[(1R)-phenylethylamino]-3-methoxycarbonylpiperidine hydrochloride; (3S,4S)-Methoxycarbonyl-PE-TEMPO hydrochloride
EINECS	Contact for details

Quality Control

Our (3S,4S)-4-[(1R)-Phenylethylamino-3-Methoxycarbonyl]-2,2,6,6-Tetramethylpiperidine-1-Oxyl Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure high chemical purity, chiral integrity, and radical stability, meeting the exacting standards required for research applications. Certificates of Analysis (COA) detailing purity, identity, and specific tests are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability. For long-term storage, consider keeping the container under an inert atmosphere.

Specification

Item	Specification
Appearance	Orange to red crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% de
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.