Description

1-[3-Fluoro-4-(Trifluoromethyl)Phenyl]Ethan-1-Amine is a specialized fluorinated aromatic amine building block of significant interest in advanced organic synthesis. Its unique structure, featuring both fluorine and a trifluoromethyl group on the phenyl ring, makes it a valuable precursor for creating compounds with tailored electronic and steric properties. This high-purity intermediate is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients, where its fluorinated motif can enhance metabolic stability, bioavailability, and binding affinity.

Application

• Pharmaceutical Intermediate: A key building block in the research and synthesis of novel drug candidates, particularly for central nervous system (CNS) targets, oncology, and anti-inflammatory applications.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, where the fluorine atoms contribute to improved lipophilicity and environmental stability.
• Material Science Research: Serves as a monomer or functionalization agent in the creation of specialty polymers, liquid crystals, and organic electronic materials.
• Chemical Biology & Proteomics: Employed as a reactive handle for labeling or modifying biomolecules in probe development and bioconjugation strategies.
• Catalyst & Ligand Development: Utilized to synthesize novel chiral amines or complex ligands for asymmetric catalysis and metal-organic frameworks (MOFs).
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses serving the fine chemical and life science industries.

Basic Information

Product Name	1-[3-Fluoro-4-(Trifluoromethyl)Phenyl]Ethan-1-Amine
CAS No.	581813-14-1
Molecular Formula	C9H7F4N
Molecular Weight	205.15 g/mol
Synonyms	1-(3-Fluoro-4-(trifluoromethyl)phenyl)ethanamine; α-Methyl-3-fluoro-4-(trifluoromethyl)benzylamine; 1-(3-Fluoro-4-trifluoromethylphenyl)ethylamine; 3-Fluoro-α-methyl-4-(trifluoromethyl)benzenemethanamine; 1-[3-Fluoro-4-(trifluoromethyl)phenyl]ethanamine; 581813-14-1; Benzenemethanamine, 3-fluoro-α-methyl-4-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 1-[3-Fluoro-4-(Trifluoromethyl)Phenyl]Ethan-1-Amine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting critical specifications such as assay, impurity profile, and residual solvents. Our quality commitment supports applications requiring high-purity intermediates for research and cGMP-compliant development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep away from strong acids, strong bases, and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Standard Grade)
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.