Description

H2N-Peg4-Tbu CAS NO 581065-95-4 is a high-purity, amine-terminated tetraethylene glycol derivative featuring a tert-butyl ester protecting group. This bifunctional PEG linker is essential for creating stable, hydrophilic spacers in bioconjugation and pharmaceutical development, enhancing solubility and reducing immunogenicity. It is a critical building block for researchers and manufacturers in the fields of proteomics, antibody-drug conjugate (ADC) development, and peptide synthesis.

Application

• Antibody-Drug Conjugate (ADC) Linker Synthesis: Serves as a key component for constructing cleavable or non-cleavable linkers, connecting cytotoxic payloads to monoclonal antibodies.
• Peptide & Protein Modification: Used to introduce PEG chains (PEGylation) to improve pharmacokinetic properties, stability, and solubility of therapeutic peptides and proteins.
• Bioconjugation & Cross-linking: The primary amine group enables conjugation to carboxylic acids, aldehydes, and other reactive sites on biomolecules for labeling and immobilization.
• Polymer Chemistry & Material Science: Acts as a functional monomer or initiator for synthesizing specialized PEG-based hydrogels, coatings, and smart materials.
• Diagnostic Reagent Development: Utilized in the preparation of fluorescent probes, MRI contrast agents, and other diagnostic tools requiring a hydrophilic spacer arm.
• Solid-Phase Peptide Synthesis (SPPS): Employed as a soluble support or as a building block to introduce PEG segments into peptide sequences.

Basic Information

Product Name	H2N-Peg4-Tbu
CAS No.	581065-95-4
Molecular Formula	C17H35NO7
Molecular Weight	365.47 g/mol
Synonyms	2,5,8,11-Tetraoxatetradecan-14-oic acid, 14-amino-13-oxo-, 1,1-dimethylethyl ester; 15-Amino-4,7,10,13-tetraoxapentadecan-1-oic acid tert-butyl ester; Amine-PEG4-t-butyl ester; Boc-NH-PEG4-acid; 4,7,10,13-Tetraoxa-16-azaheptadecanoic acid, 17-oxo-, 1,1-dimethylethyl ester; Amino-PEG4-COOtBu; tert-Butyl 15-amino-4,7,10,13-tetraoxapentadecan-1-oate
EINECS	Contact for details

Quality Control

Our H2N-Peg4-Tbu is manufactured under strict quality management systems to ensure batch-to-batch consistency for critical research and production applications. We provide comprehensive analytical data, including HPLC purity, NMR, and mass spectrometry verification. Certificates of Analysis (COA) detailing all specifications are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a desiccated environment to prevent degradation. For long-term storage (over 12 months), consider storing at 2-8°C under an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.