Description

n-(4,6-Dimethylpyrimidin-2-Yl)-5-Phenyl-4,5-Dihydro-1H-Pyrazole-1-Carboximidamide is a high-purity, advanced pharmaceutical intermediate of significant commercial and research interest. This compound is valued for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring complex heterocyclic scaffolds. It is primarily sought by pharmaceutical R&D laboratories, fine chemical manufacturers, and agrochemical research facilities for developing next-generation compounds.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Research: Serves as a core structure for developing new classes of pesticides and herbicides with potential novel modes of action.
• Chemical Biology & Proteomics: Used as a specialized ligand or probe in biochemical assays and target identification studies due to its specific binding properties.
• Material Science Research: Investigated as a monomer or additive for creating specialty polymers with unique thermal or optical properties.
• Academic & Contract Research: Essential for synthetic chemistry research in universities and CROs (Contract Research Organizations) focusing on heterocyclic and medicinal chemistry.
• Custom Synthesis & Scale-Up: Supplied for process development and optimization from milligram to multi-kilogram scale under cGMP or non-GMP conditions.

Basic Information

Product Name	n-(4,6-Dimethylpyrimidin-2-Yl)-5-Phenyl-4,5-Dihydro-1H-Pyrazole-1-Carboximidamide
CAS No.	577791-34-5
Molecular Formula	C₁₆H₁₈N₆
Molecular Weight	294.36 g/mol
Synonyms	5-Phenyl-4,5-dihydro-1H-pyrazole-1-carboximidamide, N-(4,6-dimethyl-2-pyrimidinyl)-; 1H-Pyrazole-1-carboximidamide, 4,5-dihydro-5-phenyl-N-(4,6-dimethyl-2-pyrimidinyl)-; 577791-34-5; 2-[(5-Phenyl-4,5-dihydro-1H-pyrazol-1-yl)carbonyl]guanidine, 4,6-dimethylpyrimidine derivative; N-(4,6-Dimethylpyrimidin-2-yl)-5-phenyl-4,5-dihydro-1H-pyrazole-1-carboximidamide; Pyrazole-pyrimidine carboximidamide derivative
EINECS	Contact for details

Quality Control

Our n-(4,6-Dimethylpyrimidin-2-Yl)-5-Phenyl-4,5-Dihydro-1H-Pyrazole-1-Carboximidamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis, to ensure compliance with stringent specifications. Certificates of Analysis (COA) with complete traceability are provided for every shipment. We support development under quality agreements and can supply material suitable for research use, pilot plant, or cGMP manufacturing scales.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment. For long-term storage, consider inert atmosphere conditions to ensure optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.