Description

(R)-(+)-2,2',6,6'-Tetramethoxy-4,4'-Bis(Diphenylphosphino)-3,3'-Bipyridine(1,5-Cyclooctadiene)Rhodium(I) Tetrafluoroborate is a highly specialized, chiral organometallic complex designed for asymmetric catalysis. This compound matters for its role as a precise and efficient catalyst in enantioselective synthesis, enabling the production of single-isomer chiral molecules. It is critically needed by R&D chemists and process engineers in the pharmaceutical, agrochemical, and fine chemical industries for developing advanced synthetic routes.

Application

• Asymmetric Hydrogenation: A key catalyst for the enantioselective reduction of prochiral olefins, enamides, and ketones to produce chiral intermediates.
• Pharmaceutical Intermediate Synthesis: Enables the production of single-enantiomer active pharmaceutical ingredients (APIs) for drugs targeting CNS disorders, cardiovascular diseases, and more.
• Agrochemical Manufacturing: Used in the synthesis of chiral herbicides, fungicides, and pesticides where biological activity is enantiomer-specific.
• Fine Chemical and Fragrance Production: Facilitates the creation of high-value chiral compounds for flavors, fragrances, and specialty materials.
• Methodology Development in Academic & Industrial R&D: Serves as a benchmark catalyst for developing new asymmetric catalytic transformations.
• Process Chemistry Optimization: Employed in scaling up laboratory synthetic routes to commercial manufacturing processes with high enantiomeric excess (ee).

Basic Information

Product Name	(R)-(+)-2,2',6,6'-Tetramethoxy-4,4'-Bis(Diphenylphosphino)-3,3'-Bipyridine(1,5-Cyclooctadiene)Rhodium(I) Tetrafluoroborate
CAS No.	573718-56-6
Molecular Formula	C52H52BF4N2O4P2Rh
Molecular Weight	1000.66 g/mol
Synonyms	(R)-DTBM-SEGPHOS Rh(I) COD Tetrafluoroborate; (R)-2,2',6,6'-Tetramethoxy-4,4'-bis(diphenylphosphino)-3,3'-bipyridine(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; (R)-DTBM-SEGPHOS-Rh(COD)BF4; Rhodium(I) (R)-DTBM-SEGPHOS (1,5-cyclooctadiene) tetrafluoroborate; (R)-5,5'-Bis(diphenylphosphino)-4,4'-bi-1,3-benzodioxole Rh(COD)BF4 derivative; Asymmetric hydrogenation catalyst Rh-DTBM-SEGPHOS; [Rh((R)-DTBM-SEGPHOS)(COD)]BF4
EINECS	Contact for details

Quality Control

Every batch of our (R)-DTBM-SEGPHOS-Rh(COD)BF4 catalyst is synthesized and handled under strict inert atmosphere conditions to preserve its catalytic activity. We employ advanced analytical techniques including HPLC, NMR (¹H and ³¹P), and elemental analysis to ensure identity, purity, and enantiomeric integrity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment, supporting compliance with cGMP and ISO 9001 standards for traceability and quality assurance.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store the product in a freezer at -20°C to -10°C under an inert atmosphere (argon or nitrogen). The material is both moisture-sensitive (hygroscopic) and air-sensitive (easily oxidized); therefore, the original container should only be opened in a controlled glovebox or under a positive pressure of inert gas. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Orange to red-brown crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure (¹H, ³¹P)
Purity (HPLC)	≥ 98.0%
Rhodium Content	10.0 - 10.5% (Theoretical: 10.29%)
Solubility	Soluble in dichloromethane, chloroform, THF; sparingly soluble in toluene

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.