Description

Cyclobutanepropanoic Acid, α-Amino-, Ethyl Ester, Hydrochloride is a high-purity, non-natural amino acid derivative with a constrained cyclobutane ring system, serving as a critical chiral building block in advanced organic synthesis. Its primary value lies in enabling the construction of complex, sterically defined molecular architectures for pharmaceutical research and development. This compound is essential for medicinal chemists and process R&D teams in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop novel active ingredients with improved metabolic profiles.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of peptide mimetics, protease inhibitors, and other bioactive molecules targeting neurological and metabolic disorders.
• Agrochemical Research: Used in the development of novel herbicides and pesticides with specific chiral activity.
• Peptidomimetics & Constrained Peptides: The cyclobutane backbone provides rigidity, making it valuable for designing stable peptide analogs and macrocyclic compounds.
• Chemical Biology Probes: Incorporation into molecular probes to study enzyme-substrate interactions and protein function.
• Asymmetric Synthesis: Serves as a starting material or auxiliary in catalytic asymmetric reactions to introduce chirality.
• Material Science: Potential monomer for creating novel polymers with unique thermal and mechanical properties.

Basic Information

Item	Detail
Product Name	Cyclobutanepropanoic Acid, α-Amino-, Ethyl Ester, Hydrochloride
CAS No.	565456-74-8
Molecular Formula	C9H17NO2·HCl
Molecular Weight	207.70 g/mol (Free base: 171.24 g/mol)
Synonyms	Ethyl 3-Amino-3-cyclobutanepropanoate Hydrochloride; 3-Amino-3-cyclobutanepropanoic Acid Ethyl Ester Hydrochloride; 3-Cyclobutyl-3-aminopropionic Acid Ethyl Ester HCl; (3-Amino-3-cyclobutyl-propionic acid)-ethyl ester hydrochloride; α-Aminocyclobutanepropanoic Acid Ethyl Ester Hydrochloride; 1-(Ethoxycarbonyl)-2-cyclobutylethylamine Hydrochloride; Cyclobutanepropanoic acid, α-amino-, ethyl ester, hydrochloride (1:1)
EINECS	Contact for details

Quality Control

Every batch of Cyclobutanepropanoic Acid, α-Amino-, Ethyl Ester, Hydrochloride is manufactured under a strict quality management system and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, detailing key parameters such as assay, enantiomeric excess, and impurity profiles. Our production adheres to cGMP standards where applicable, supporting its use in regulated research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere or in a desiccator after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.