Description

Tetrakis[n-Tetrafluorophthaloyl-(S)-tert-Leucinato]Dirhodium Bis(Ethyl Acetate) Adduct is a highly specialized, chiral dirhodium(II) carboxylate complex designed for asymmetric catalysis. This compound matters for its exceptional ability to facilitate enantioselective C-H functionalization and cyclopropanation reactions with high selectivity and yield. It is critically needed by pharmaceutical R&D departments and fine chemical manufacturers for the synthesis of chiral intermediates and active pharmaceutical ingredients (APIs).

Application

• Asymmetric C-H Amination: A key catalyst for the enantioselective insertion of nitrogen into C-H bonds, crucial for synthesizing chiral amines.
• Enantioselective Cyclopropanation: Enables the synthesis of chiral cyclopropane rings, important structural motifs in medicinal chemistry and agrochemicals.
• Pharmaceutical Intermediate Synthesis: Used in the production of enantiomerically pure intermediates for drug candidates targeting CNS disorders, oncology, and infectious diseases.
• Asymmetric Si-H Insertion: Catalyzes the formation of chiral organosilicon compounds with applications in materials science and as synthetic building blocks.
• Academic & Industrial R&D: A valuable tool for method development in organic synthesis and process chemistry within university and corporate laboratories.
• Scale-up Process Development: Suitable for transitioning asymmetric transformations from milligram to kilogram scale in pilot plants.

Basic Information

Item	Detail
Product Name	Tetrakis[n-Tetrafluorophthaloyl-(S)-tert-Leucinato]Dirhodium Bis(Ethyl Acetate) Adduct
CAS No.	564450-56-2
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Dirhodium(II) Tetrakis[n-Tetrafluorophthaloyl-(S)-tert-leucinate] Ethyl Acetate Adduct; Rh2(S-TFPTTL)4; Rh2(S-TFPTTL)4•(EtOAc)2; Chiral Dirhodium(II) Carboxylate Catalyst; Rh2(S-TFPTTL)4 Adduct; Asymmetric Dirhodium Catalyst; Dirhodium Tetrakis(α,α,α,α-tetrafluoro-N-phthaloyl-(S)-tert-leucinate); Dirhodium(II) Tetra(S-TFPTTL)
EINECS	Contact for details

Quality Control

Every batch of our Tetrakis[n-Tetrafluorophthaloyl-(S)-tert-Leucinato]Dirhodium Bis(Ethyl Acetate) Adduct undergoes rigorous analytical testing to ensure high catalytic activity and enantiomeric purity. Our quality protocols are designed to meet the stringent requirements of pharmaceutical development. A comprehensive Certificate of Analysis (COA) detailing purity, chiral integrity, and spectroscopic data is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., argon or nitrogen) at 2-8°C. This material is hygroscopic (moisture-sensitive) and easily oxidized; ensure containers are sealed immediately after use to exclude moisture and air.

Specification

Item	Specification
Appearance	Dark green to purple crystalline solid
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 95.0%
Rhodium Content	Contact for details
Solvent Content (NMR)	Residual solvents meet ICH guidelines
Moisture Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.