Description

7'-Aminospiro[Cyclopropane-1,4'(1'H)-Isoquinoline]-2'(3'H)Carboxylic Acid 1,1-Dimethyl Ester is a high-value, structurally complex organic building block featuring a fused spirocyclic system. This compound matters as a critical intermediate in modern pharmaceutical research, particularly for the synthesis of novel bioactive molecules targeting central nervous system disorders. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries for lead optimization and the development of new therapeutic agents.

Application

• Pharmaceutical Intermediate: Key synthetic precursor for the development of novel drug candidates, especially in neurological and psychiatric therapeutic areas.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead compound optimization due to its unique spirocyclic scaffold.
• Chemical Biology Probes: Serves as a core structure for designing molecular probes to study enzyme function and receptor interactions.
• Process Chemistry Development: Employed in scaling up synthetic routes for active pharmaceutical ingredients (APIs) under Good Manufacturing Practice (GMP) conditions.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting drug discovery and development pipelines.
• Academic Research: Utilized in university and institutional labs for pioneering research in organic synthesis and heterocyclic chemistry.

Basic Information

Product Name	7'-Aminospiro[Cyclopropane-1,4'(1'H)-Isoquinoline]-2'(3'H)Carboxylic Acid 1,1-Dimethyl Ester
CAS No.	561297-88-9
Molecular Formula	C15H18N2O2
Molecular Weight	258.32 g/mol
Synonyms	1,1-Dimethyl 7'-Aminospiro[cyclopropane-1,4'(1'H)-isoquinoline]-2'(3'H)-dicarboxylate; 7'-Amino-1,1-dimethoxycarbonylspiro[cyclopropane-1,4'-isoquinoline]; Spiro[cyclopropane-1,4'(1'H)-isoquinoline]-2'(3'H)-carboxylic acid, 7'-amino-, 1,1-dimethyl ester; Aminospirocyclopropaneisoquinolinedicarboxylic Acid Dimethyl Ester
EINECS	Contact for details

Quality Control

Every batch of 7'-Aminospiro[Cyclopropane-1,4'(1'H)-Isoquinoline]-2'(3'H)Carboxylic Acid 1,1-Dimethyl Ester is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure identity, purity, and consistency for your critical research and development applications. A detailed Certificate of Analysis (COA) including HPLC purity, NMR, and mass spectrometry data is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). For long-term storage, consider keeping the material under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.