Description

(2R,3S)-3-(3-Chlorophenyl)Oxirane-2-Carboxamide is a high-purity, stereochemically defined chiral epoxide derivative, serving as a critical advanced pharmaceutical intermediate (API) and a versatile building block in asymmetric synthesis. Its precise stereochemistry and functional groups make it invaluable for constructing complex molecular architectures with high enantiomeric purity. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key chiral precursor for the synthesis of potential drug candidates, particularly in central nervous system (CNS) and anti-inflammatory therapeutic areas.
• Asymmetric Synthesis: A versatile electrophilic building block for nucleophilic ring-opening reactions to introduce chiral 1,2-amino alcohol or diol motifs.
• Agrochemical Research: Intermediate in the development of new-generation, stereoselective pesticides and herbicides.
• Ligand and Catalyst Development: Used in the preparation of chiral ligands for transition metal catalysis.
• Fine Chemical Production: Employed in the custom synthesis of specialty chemicals requiring high enantiopurity.
• Academic & R&D: A valuable tool compound for methodological studies in organic and medicinal chemistry.

Basic Information

Product Name	(2R,3S)-3-(3-Chlorophenyl)Oxirane-2-Carboxamide
CAS No.	556053-64-6
Molecular Formula	C9H8ClNO2
Molecular Weight	197.62 g/mol
Synonyms	(2R,3S)-3-(3-Chlorophenyl)glycidamide; trans-3-(3-Chlorophenyl)glycidamide; (2R,3S)-3-(3-Chlorophenyl)-2,3-epoxypropanamide; 3-(3-Chlorophenyl)oxirane-2-carboxamide, (2R,3S)-; (2R,3S)-Epoxypropion-m-chloroanilide; AR-A2 (research code); A chiral chlorophenyl glycidamide derivative.
EINECS	Contact for details

Quality Control

Our (2R,3S)-3-(3-Chlorophenyl)Oxirane-2-Carboxamide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric excess (ee) verification, to ensure it meets the high-purity standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.