Description

4-(Chloromethyl)-7,8-Dihydrocyclopenta[G]Chromen-2(6H)-One is a high-purity, advanced pharmaceutical intermediate characterized by its unique fused tricyclic structure. This compound is of significant commercial interest for its role as a critical building block in the synthesis of complex organic molecules, particularly in medicinal chemistry. It is primarily sought after by research institutions and pharmaceutical manufacturers engaged in the development of novel active pharmaceutical ingredients (APIs) and other fine chemicals. The precise molecular architecture offers a versatile handle for further functionalization, making it a valuable asset in targeted drug discovery programs.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of complex drug candidates, particularly those with fused ring systems.
• Medicinal Chemistry Research: Used in research and development (R&D) for constructing molecular libraries and exploring structure-activity relationships (SAR).
• Organic Synthesis Building Block: The chloromethyl group provides a reactive site for nucleophilic substitution, enabling further chemical modifications and chain extensions.
• Fine Chemical Production: Employed in the multi-step synthesis of specialty chemicals requiring a dihydrocyclopentachromenone core.
• API Development: Integral in the development pathway for new Active Pharmaceutical Ingredients, especially in oncology and central nervous system (CNS) therapeutic areas.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Product Name	4-(Chloromethyl)-7,8-Dihydrocyclopenta[G]Chromen-2(6H)-One
CAS No.	554423-45-9
Molecular Formula	C₁₃H₁₁ClO₂
Molecular Weight	234.68 g/mol
Synonyms	4-(Chloromethyl)-7,8-dihydro-6H-cyclopenta[g]chromen-2-one; 6H-Cyclopenta[g]chromen-2-one, 7,8-dihydro-4-(chloromethyl)-; 4-Chloromethyl-7,8-dihydro-6H-cyclopenta[g]chromen-2-one; 7,8-Dihydro-4-(chloromethyl)cyclopenta[g]chromen-2(6H)-one; Cyclopenta[g]chromen-2(6H)-one, 7,8-dihydro-4-(chloromethyl)-
EINECS	Contact for details

Quality Control

Our 4-(Chloromethyl)-7,8-Dihydrocyclopenta[G]Chromen-2(6H)-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Keep away from strong bases and oxidizing agents. For long-term storage, consider inert atmosphere conditions to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Assay	97.0% - 102.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.