Description

7-(Trifluoromethyl)Benzo[B]Thiophene-2-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate characterized by its benzo[b]thiophene core and trifluoromethyl functionality. This compound matters as a critical building block in modern medicinal chemistry, where the trifluoromethyl group is prized for its ability to enhance metabolic stability, membrane permeability, and binding affinity in target molecules. It is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, particularly in areas like kinase inhibitors and other small-molecule therapeutics.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, especially in oncology and central nervous system (CNS) disease research.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, leveraging the bioactivity of the thiophene scaffold.
• Material Science Research: Serves as a precursor for organic electronic materials, such as semiconductors and light-emitting diodes (OLEDs), due to its conjugated system.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and GMP production of client-specific molecules.

Basic Information

Product Name	7-(Trifluoromethyl)Benzo[B]Thiophene-2-Carboxylic Acid
CAS No.	550998-66-8
Molecular Formula	C10H5F3O2S
Molecular Weight	246.21 g/mol
Synonyms	7-(Trifluoromethyl)-1-benzothiophene-2-carboxylic acid; 7-(Trifluoromethyl)benzo[b]thiophene-2-carboxylic acid; 2-Benzo[b]thiophenecarboxylic acid, 7-(trifluoromethyl)-; 7-Trifluoromethylbenzo[b]thiophene-2-carboxylic Acid; 7-(Trifluoromethyl)-1-benzothiophene-2-carboxylate; 550998-66-8; 7-(Trifluoromethyl)benzothiophene-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our 7-(Trifluoromethyl)Benzo[B]Thiophene-2-Carboxylic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) documenting identity, purity, and impurity profiles are available for all shipments. We support compliance with relevant guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong bases and oxidizing agents. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.