Description

2-Boc-7-(tert-Butyl)-1,2,3,4-Tetrahydroisoquinoline-3-Carboxylic Acid is a high-purity, protected amino acid derivative and a key chiral building block in advanced organic synthesis. This compound matters for its role as a critical intermediate in the development of complex pharmaceutical molecules, particularly in medicinal chemistry for creating novel drug candidates. It is primarily needed by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in the synthesis of peptidomimetics, protease inhibitors, and other biologically active compounds.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates targeting neurological and metabolic disorders.
• Peptidomimetic Research: Serves as a constrained, non-natural amino acid analog for constructing peptide-like molecules with enhanced stability and bioavailability.
• Protease Inhibitor Development: Used in the design and synthesis of potent inhibitors for various proteolytic enzymes.
• Medicinal Chemistry Scaffold: Provides a versatile tetrahydroisoquinoline core for structure-activity relationship (SAR) studies and library synthesis in drug discovery.
• Asymmetric Synthesis: Employed as a chiral auxiliary or building block in stereoselective synthesis routes.
• Chemical Biology Probes: Utilized in the development of molecular probes for studying enzyme function and protein-protein interactions.

Basic Information

Product Name	2-Boc-7-(tert-Butyl)-1,2,3,4-Tetrahydroisoquinoline-3-Carboxylic Acid
CAS No.	545394-19-2
Molecular Formula	C19H27NO4
Molecular Weight	333.42 g/mol
Synonyms	1,2,3,4-Tetrahydro-7-(1,1-dimethylethyl)-2-[[(1,1-dimethylethoxy)carbonyl]amino]-3-isoquinolinecarboxylic Acid; 2-[(tert-Butoxycarbonyl)amino]-7-tert-butyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic Acid; 2-(Boc-amino)-7-tert-butyl-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic Acid; 7-tert-Butyl-2-((tert-butoxycarbonyl)amino)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic Acid; 2-Boc-7-tert-butyl-Tic-OH; (3S)-2-[(tert-Butoxycarbonyl)amino]-7-tert-butyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic Acid (for enantiomer); BOC-7-T-BUTYL-TIC-OH
EINECS	Contact for details

Quality Control

Our 2-Boc-7-(tert-Butyl)-1,2,3,4-Tetrahydroisoquinoline-3-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee (for specified enantiomer)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.