Description

Quinoline, 1-(Chloroacetyl)-6-Fluoro-1,2,3,4-Tetrahydro-2-Methyl- (9Ci) is a high-value, multi-functional heterocyclic building block designed for advanced synthetic chemistry. This compound is critical for research and development in the pharmaceutical sector, where its unique molecular scaffold enables the creation of novel active pharmaceutical ingredients (APIs). It is primarily sought after by medicinal chemists and process development scientists working on innovative drug discovery programs, particularly in oncology and central nervous system (CNS) therapeutic areas.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, especially those targeting specific enzyme inhibitors.
• Medicinal Chemistry Research: Used as a core scaffold for constructing libraries of novel compounds in high-throughput screening and structure-activity relationship (SAR) studies.
• API Development: Serves as a critical building block in the multi-step synthesis of potential Active Pharmaceutical Ingredients (APIs).
• Agrochemical Research: Employed in the development of new herbicides and pesticides due to its bioactive quinoline core.
• Organic Synthesis: Utilized in academic and industrial labs for exploring new organic reactions and synthesizing complex heterocyclic molecules.
• Chemical Reference Standard: Supplied as a high-purity standard for analytical method development and quality control in pharmaceutical manufacturing.

Basic Information

Product Name	Quinoline, 1-(Chloroacetyl)-6-Fluoro-1,2,3,4-Tetrahydro-2-Methyl- (9Ci)
CAS No.	544692-44-6
Molecular Formula	C12H13ClFNO
Molecular Weight	241.69 g/mol
Synonyms	1-(Chloroacetyl)-6-fluoro-2-methyl-1,2,3,4-tetrahydroquinoline; 6-Fluoro-2-methyl-1,2,3,4-tetrahydroquinolin-1-yl-chloroethanone; 1-Chloroacetyl-6-fluoro-2-methyl-1,2,3,4-tetrahydroquinoline; 6-Fluoro-2-methyl-1-(2-chloroacetyl)-1,2,3,4-tetrahydroquinoline; Tetrahydroquinoline derivative (CAS 544692-44-6); 1,2,3,4-Tetrahydro-6-fluoro-2-methylquinolin-1-yl 2-chloroethanone
EINECS	Contact for details

Quality Control

Our Quinoline, 1-(Chloroacetyl)-6-Fluoro-1,2,3,4-Tetrahydro-2-Methyl- (9Ci) is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to quality supports compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases and oxidizing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.