Description

6-Bromoquinazoline-4-Thiol is a versatile and high-value heterocyclic building block, primarily utilized in advanced pharmaceutical research and development. Its core value lies in its functionalized quinazoline scaffold, which serves as a critical precursor for synthesizing targeted kinase inhibitors and other bioactive molecules. This compound is essential for medicinal chemists and R&D teams in the pharmaceutical, agrochemical, and fine chemical industries seeking to develop new therapeutic agents.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel kinase inhibitors, particularly for oncology and anti-inflammatory drug candidates.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes due to its modifiable bromo and thiol functional groups.
• Agrochemical Synthesis: Serves as a building block for creating new active ingredients with potential herbicidal or fungicidal properties.
• Fine Chemical Production: Employed in the custom synthesis of complex, high-value specialty chemicals for various industrial applications.
• Bioconjugation & Probe Development: The thiol group allows for conjugation chemistry, useful in creating biochemical probes and labeled compounds for diagnostic research.

Basic Information

Product Name	6-Bromoquinazoline-4-Thiol
CAS No.	544461-20-3
Molecular Formula	C8H5BrN2S
Molecular Weight	241.11 g/mol
Synonyms	4-Mercapto-6-bromoquinazoline; 6-Bromo-4-quinazolinethiol; 6-Bromo-4-mercaptoquinazoline; Quinazoline-4-thiol, 6-bromo-; 6-Bromoquinazoline-4-thione (tautomer); 4-Thiol-6-bromoquinazoline; 6-Bromo-4-sulfanylquinazoline
EINECS	Contact for details

Quality Control

Our 6-Bromoquinazoline-4-Thiol is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity verification and NMR/LC-MS for structural confirmation, to ensure it meets the exacting standards required for research and development. A Certificate of Analysis (COA) detailing all specifications is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place at 2-8°C to minimize oxidation and degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.