Description

2-(2,6-Difluoro-4-Nitrophenyl)Acetic Acid is a high-purity, fluorinated aromatic building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of active pharmaceutical ingredients (APIs) and agrochemicals, where its difluoro and nitro substituents enable precise structural modifications. It is primarily needed by research and development chemists, process development teams, and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and pesticides, where the fluorine atoms enhance biological activity and environmental stability.
• Liquid Crystal & OLED Material Research: Serves as a building block for fluorinated aromatic cores in electronic and optoelectronic materials.
• Chemical Biology & Proteomics: Employed in the design and synthesis of activity-based probes and molecular tags for studying biological systems.
• Custom Synthesis & Contract Manufacturing: Supplied to CROs and CDMOs for client-specific projects requiring fluorinated nitroaromatic intermediates.
• Academic & Industrial R&D: Used in research laboratories for method development and exploring new synthetic pathways involving fluorinated compounds.

Basic Information

Product Name	2-(2,6-Difluoro-4-Nitrophenyl)Acetic Acid
CAS No.	543683-36-9
Molecular Formula	C8H5F2NO4
Molecular Weight	217.13 g/mol
Synonyms	(2,6-Difluoro-4-nitrophenyl)acetic acid; 2-(2,6-Difluoro-4-nitrophenyl)ethanoic acid; 4-Nitro-2,6-difluorophenylacetic acid; Acetic acid, 2-(2,6-difluoro-4-nitrophenyl)-; 543683-36-9; 2,6-Difluoro-4-nitrophenylacetic acid; α-(2,6-Difluoro-4-nitrophenyl)acetic acid
EINECS	Contact for details

Quality Control

Our 2-(2,6-Difluoro-4-Nitrophenyl)Acetic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for synthetic applications. Certificates of Analysis (COA) with detailed specifications are provided for each lot to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.