Description

5-[(1,3-Dioxo-1,3-Dihydro-2H-Isoindol-2-Yl)Methyl]-2-Iodobenzoic Acid is a high-purity, advanced pharmaceutical intermediate characterized by its unique molecular architecture combining a phthalimide-protected amine moiety with an iodinated benzoic acid. This compound matters as a critical building block for the synthesis of complex, biologically active molecules, offering precise functionalization points for medicinal chemistry research and development. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients and fine-tuning molecular properties.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization due to its reactive iodine and protected amine functional groups.
• Peptidomimetic Synthesis: The phthalimide (NPhth) protecting group makes it valuable for constructing peptide analogs and peptidomimetics.
• Ligand and Catalyst Development: Employed in the development of specialized ligands for transition metal catalysis and organocatalysis.
• Agrochemical Active Ingredient Synthesis: Acts as a building block for developing new herbicides, fungicides, or insecticides with tailored activity.
• Material Science Precursor: Potential use in synthesizing functionalized monomers for advanced polymers or organic electronic materials.
• Cross-Coupling Reactions: The aryl iodide moiety is ideal for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to create complex biaryl structures.
• Chemical Biology Probes: Can be utilized to develop molecular probes for studying biological pathways and protein interactions.

Basic Information

Item	Details
Product Name	5-[(1,3-Dioxo-1,3-Dihydro-2H-Isoindol-2-Yl)Methyl]-2-Iodobenzoic Acid
CAS No.	540513-92-6
Molecular Formula	C16H10INO4
Molecular Weight	407.16 g/mol
Synonyms	2-Iodo-5-[(1,3-dioxoisoindolin-2-yl)methyl]benzoic acid; 2-Iodo-5-(phthalimidomethyl)benzoic acid; 5-(Phthalimidomethyl)-2-iodobenzoic acid; N-(2-Iodo-5-carboxybenzyl)phthalimide; 540513-92-6; Benzoic acid, 2-iodo-5-[(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)methyl]-; 2-Iodo-5-(1,3-dioxoisoindolin-2-ylmethyl)benzoic acid
EINECS	Contact for details

Quality Control

Every batch of 5-[(1,3-Dioxo-1,3-Dihydro-2H-Isoindol-2-Yl)Methyl]-2-Iodobenzoic Acid is manufactured under a strict quality management system and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our standard pharmaceutical intermediate grade meets exacting specifications for use in research and development. A comprehensive Certificate of Analysis (COA) detailing purity (typically by HPLC), identity confirmation (IR, NMR), and impurity profiles is provided with each shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.