Description

Tricyclohexylphosphine[3-Phenyl-1H-Inden-1-Ylidene][1,3-Bis(2,4,6-Trimethylphenyl)-4,5-Dihydroimidazol-2-Ylidene]Ruthenium(II) is a highly specialized, second-generation Grubbs-Hoveyda type olefin metathesis catalyst. This compound matters for its exceptional activity, thermal stability, and functional group tolerance, enabling efficient and selective carbon-carbon double bond formation in complex molecular architectures. It is critically needed by R&D chemists and process engineers in the pharmaceutical, agrochemical, and advanced materials sectors for synthesizing active pharmaceutical ingredients (APIs), fine chemicals, and specialty polymers.

Application

• Pharmaceutical Intermediate Synthesis: Key catalyst for ring-closing metathesis (RCM), cross metathesis (CM), and ring-opening metathesis polymerization (ROMP) in the production of complex, biologically active molecules and APIs.
• Agrochemical Development: Used in the synthesis of novel herbicides, fungicides, and insecticides requiring precise olefin metathesis steps.
• Advanced Material & Polymer Science: Enables the creation of specialty polymers, functionalized surfaces, and smart materials via controlled ROMP and CM reactions.
• Fine Chemical & Specialty Chemical Manufacturing: Facilitates the efficient, scalable synthesis of high-value fragrance ingredients, flavors, and other complex organic compounds.
• Academic & Industrial R&D: An essential tool for methodology development and exploring new synthetic pathways in organic and organometallic chemistry laboratories.
• Process Chemistry & Scale-Up: Valued for its robustness and consistent performance in transitioning from laboratory-scale discovery to pilot and commercial-scale production.

Basic Information

Item	Details
Product Name	Tricyclohexylphosphine[3-Phenyl-1H-Inden-1-Ylidene][1,3-Bis(2,4,6-Trimethylphenyl)-4,5-Dihydroimidazol-2-Ylidene]Ruthenium(II)
CAS No.	536724-67-1
Molecular Formula	C54H68N2PRu
Molecular Weight	888.16 g/mol
Synonyms	Grubbs-Hoveyda Catalyst 2nd Generation; Hoveyda-Grubbs Catalyst 2nd Gen; (1,3-Bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene)dichloro(3-phenyl-1H-inden-1-ylidene)(tricyclohexylphosphine)ruthenium; HG II; Dichloro[1,3-bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene][(3-phenyl-1H-inden-1-ylidene)](tricyclohexylphosphine)ruthenium(II); Ru-Ind Catalyst; Zhan Catalyst 1B; [RuCl2(IMesH2)(PCy3)(Ind)]
EINECS	Contact for details

Quality Control

Every batch of our Grubbs-Hoveyda type catalyst is manufactured and tested under stringent quality protocols to ensure high purity, catalytic activity, and batch-to-batch consistency. Our quality system adheres to cGMP principles where applicable. Comprehensive Certificates of Analysis (COA) are provided with each shipment, detailing key parameters such as assay (Ru content), identity by spectroscopic methods, and impurity profiles to meet the exacting standards of process chemistry and regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C in a dry, cool environment. This compound is easily oxidized and hygroscopic; prolonged exposure to air, moisture, or elevated temperatures will degrade catalytic performance. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Dark purple to brown crystalline solid
Identification (IR)	Conforms to structure
Assay (Ru, by ICP-OES)	≥ 98.0%
Purity (HPLC)	≥ 97.0%
Solubility	Soluble in common organic solvents (DCM, toluene, THF)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.