Description

2-((6-Iodohex-2-Yn-1-Yl)Oxy)Tetrahydro-2H-Pyran is a specialized organic intermediate featuring a protected hydroxyl group and a terminal iodoalkyne moiety. This unique bifunctional structure makes it a valuable building block for advanced organic synthesis, particularly in the construction of complex molecular architectures. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for applications such as click chemistry, cross-coupling reactions, and polymer modification.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the synthesis of active pharmaceutical ingredients (APIs) and novel drug candidates, leveraging its alkyne and halogen functionalities for selective coupling reactions.
• Agrochemical Synthesis: Used in the research and development of new pesticides and herbicides, where its reactive groups allow for the introduction of specific bioactive moieties.
• Click Chemistry Reagent: The terminal iodoalkyne group is amenable to copper-catalyzed azide-alkyne cycloaddition (CuAAC), making it useful for bioconjugation, polymer functionalization, and materials surface modification.
• Cross-Coupling Reactions: Acts as a substrate in Sonogashira, Heck, and other palladium-catalyzed cross-coupling reactions to form carbon-carbon bonds for complex molecule assembly.
• Polymer & Materials Science: Employed as a monomer or functionalization agent in the development of specialty polymers, dendrimers, and advanced materials with tailored properties.
• Ligand & Catalyst Development: Useful for synthesizing novel ligands and organometallic catalysts for asymmetric synthesis and other catalytic processes.

Basic Information

Product Name	2-((6-Iodohex-2-Yn-1-Yl)Oxy)Tetrahydro-2H-Pyran
CAS No.	532414-06-5
Molecular Formula	C11H17IO2
Molecular Weight	308.16 g/mol
Synonyms	6-Iodo-2-hexynyl tetrahydropyranyl ether; THP-Protected 6-iodo-2-hexyn-1-ol; 2H-Pyran, 2-[(6-iodo-2-hexyn-1-yl)oxy]tetrahydro-; 2-((6-Iodohex-2-yn-1-yl)oxy)tetrahydro-2H-pyran; 6-Iodo-2-hexynyl THP ether; 2-(6-Iodohex-2-ynyloxy)tetrahydropyran; Tetrahydropyran-2-yl 6-iodohex-2-ynyl ether
EINECS	Contact for details

Quality Control

Our 2-((6-Iodohex-2-Yn-1-Yl)Oxy)Tetrahydro-2H-Pyran is manufactured under strict quality management protocols. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for research and process chemistry. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain product integrity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.